KLF13 - KLF transcription factor 13 Gene

Also Known as BTEB3; FKLF2; NSLP1; RFLAT1; RFLAT-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51621

About KLF13

Cytogenetic location: 15q13.3 Genomic coordinates (GRCh38): 15:31,326,835-31,435,665 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 118 orthologues, 22 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 34.5), lung (RPKM 27.2) and 24 other tissues.

Summary

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

KLF13 Products (2)

mRNA	Protein	Name
NM_001302461.2	NP_001289390.1	Krueppel-like factor 13 isoform 2
NM_015995.4	NP_057079.2	Krueppel-like factor 13 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17053787	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF13 Protein Structure

zf-H2C2_2

0
100
200
288 a.a.

Protein Preferred Names	Protein Names
Krueppel-like factor 13	BTE-binding protein 3

KLF13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KLF13	Q9Y2Y9	PRP4K	Homo sapiens	Q13523	Protein Kinase Assay	17513757
Intra	KLF13	Q9Y2Y9	PRP4K	Homo sapiens	Q13523	Anti Tag CoIP	17513757
Intra	KLF13	Q9Y2Y9	GATA4	Homo sapiens	P43694	Anti Tag CoIP	17053787

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 15q13.3 Deletion Syndrome	Chromosome 15q13.3 Microdeletion Syndrome 15q13.3 Microdeletion Syndrome 15q13.3 Microdeletion Microdeletion 15q13.3 Syndrome Del(15)(Q13.3) Monosomy 15q13.3
Tricuspid Valve Stenosis	Tricuspid Stenosis Tricuspid Stricture Tricuspid Valve Stricture Tricuspid Insufficiency With Obstruction Tricuspid Insufficiency With Stenosis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07334	KLF13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22599	Klf13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29116	Klf13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLF13	RGD	RGD:1565099
Bos taurus	KLF13	VGNC	VGNC:106796
Mus musculus	KLF13	MGD	MGI:1354948
Macaca mulatta	KLF13	VGNC	VGNC:84365
Felis catus	KLF13	VGNC	VGNC:80941
Others	KLF13	NCBI