STK38 - serine/threonine kinase 38 Gene

Also Known as NDR; NDR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11329

About STK38

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,493,892-36,547,479 (from NCBI)

This gene has 1 transcript (splice variant), 250 orthologues and 1 paralogue. Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues.

Summary

This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by Other upstream kinases. This protein has been shown to function in the cell cycle and Apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

STK38 Products (2)

mRNA Protein Name
NM_001305102.2 NP_001292031.1 serine/threonine-protein kinase 38
NM_007271.4 NP_009202.1 serine/threonine-protein kinase 38

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12493777 GOA
enables UFM1-modified protein reader activity IDA
IDA: Inferred from direct assay
32537488 GOA
enables histone reader activity IDA
IDA: Inferred from direct assay
32537488 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12493777 GOA
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
17906693 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9774336 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12493777 GOA
enables ubiquitin-like protein reader activity IDA
IDA: Inferred from direct assay
32537488 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
32537488 GOA
involved in DNA damage response IDA
IDA: Inferred from direct assay
32537488 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12493777 GOA
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
17906693 GOA
involved in protein modification process IDA
IDA: Inferred from direct assay
7761441 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12493777 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17906693 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12493777 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
32537488 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK38 Protein Structure

Pkinase

Pkinase: Protein kinase domain (90 - 364)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (401 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 38

  • NDR1 protein kinase

STK38 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STK38 Q15208 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
STK38 Q15208 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
STK38 Q15208 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
STK38 Q15208 MOB2 Homo sapiens Q70IA6
Anti Tag CoIP
25852190
Intra
STK38 Q15208 MOB2 Homo sapiens Q70IA6
Pull Down
32707033
Intra
STK38 Q15208 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
STK38 Q15208 NCK1 Homo sapiens P16333
Anti Bait CoIP
31980649
Intra
STK38 Q15208 ARRB1 Homo sapiens P49407
Anti Tag CoIP
17620599
Intra
STK38 Q15208 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
15197186
Intra
STK38 Q15208 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
25852190
Cross
STK38 Q15208 S100B Bos taurus P02638
NMR
14661952
Cross
STK38 Q15208 S100B Bos taurus P02638
Affinity Chrom
9774336
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10211 Tanespimycin 99.01% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13939 STK38L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10211S Tanespimycin-d5 / Unkown
HY-RS13938 STK38 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18409 Stk38 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24890 Stk38 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STK38 VGNC VGNC:46919
Felis catus STK38 VGNC VGNC:65786
Mus musculus STK38 MGD MGI:2442572
Rattus norvegicus STK38 RGD RGD:1309455
Macaca mulatta STK38 VGNC VGNC:78155
Bos taurus STK38 VGNC VGNC:35399
Others STK38 NCBI