TRAPPC2L - trafficking protein particle complex subunit 2L Gene

Also Known as PERRB; HSPC176

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51693

About TRAPPC2L

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,856,220-88,862,678 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 16.3), testis (RPKM 13.9) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

TRAPPC2L Products (9)

mRNA Protein Name
NM_001318524.2 NP_001305453.1 trafficking protein particle complex subunit 2-like protein isoform 1
NM_001318525.2 NP_001305454.1 trafficking protein particle complex subunit 2-like protein isoform 3
NM_001318526.2 NP_001305455.1 trafficking protein particle complex subunit 2-like protein isoform 4
NM_001318527.2 NP_001305456.1 trafficking protein particle complex subunit 2-like protein isoform 5
NM_001318528.2 NP_001305457.1 trafficking protein particle complex subunit 2-like protein isoform 6
NM_001318529.2 NP_001305458.1 trafficking protein particle complex subunit 2-like protein isoform 7
NM_001318530.2 NP_001305459.1 trafficking protein particle complex subunit 2-like protein isoform 8
NM_001318532.2 NP_001305461.1 trafficking protein particle complex subunit 2-like protein isoform 9
NM_016209.5 NP_057293.1 trafficking protein particle complex subunit 2-like protein isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Références Source
part of TRAPP complex IDA
IDA: Inferred from direct assay
21525244 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC2L Protein Structure

Sedlin_N

Sedlin_N: Sedlin, N-terminal conserved region (7 - 136)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

trafficking protein particle complex subunit 2-like protein

  • hematopoietic stem/progenitor cells 176

TRAPPC2L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TRAPPC2L Q9UL33 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra
TRAPPC2L Q9UL33 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Array
25416956
Intra
TRAPPC2L Q9UL33 REPS1 Homo sapiens Q96D71-2
Y2H Array
25416956
Intra
TRAPPC2L Q9UL33 REPS1 Homo sapiens Q96D71-2
Y2H Prey Pooling
25416956
Intra
TRAPPC2L Q9UL33 REPS1 Homo sapiens Q96D71-3
Y2H Prey Pooling
25416956
Intra
TRAPPC2L Q9UL33 REPS1 Homo sapiens Q96D71-3
Validated Y2H
25416956
Intra
TRAPPC2L Q9UL33 REPS1 Homo sapiens Q96D71-3
Y2H Array
25416956
Intra
TRAPPC2L Q9UL33 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
25416956
Intra
TRAPPC2L Q9UL33 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
25416956
Intra
TRAPPC2L Q9UL33 TRAPPC8 Homo sapiens Q9Y2L5
Anti Tag CoIP
33961781
Intra
TRAPPC2L Q9UL33 TRAPPC8 Homo sapiens Q9Y2L5
Anti Tag CoIP
21453443
Intra
TRAPPC2L Q9UL33 TRAPPC13 Homo sapiens A5PLN9
Anti Tag CoIP
21453443
Intra
TRAPPC2L Q9UL33 TRAPPC13 Homo sapiens A5PLN9
Anti Tag CoIP
33961781
Intra
TRAPPC2L Q9UL33 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
TRAPPC2L Q9UL33 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
TRAPPC2L Q9UL33 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
TRAPPC2L Q9UL33 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
TRAPPC2L Q9UL33 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra
TRAPPC2L Q9UL33 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra
TRAPPC2L Q9UL33 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Intra
TRAPPC2L Q9UL33 TRAPPC3 Homo sapiens O43617
Y2H
21827752
Intra
TRAPPC2L Q9UL33 TRAPPC3 Homo sapiens O43617
Anti Tag CoIP
21453443
Intra
TRAPPC2L Q9UL33 TRAPPC3 Homo sapiens O43617
Validated Y2H
25416956
Intra
TRAPPC2L Q9UL33 TRAPPC3 Homo sapiens O43617
Anti Tag CoIP
33961781
Intra
TRAPPC2L Q9UL33 TRAPPC3 Homo sapiens O43617
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Encephalopathy, Progressive, Early-Onset, With Episodic Rhabdomyolysis

  • PEERB
Mucopolysaccharidosis, Type Iva

  • Mps Iva

  • Galns Deficiency

  • MPS4A

  • Morquio A Disease

  • Galactosamine-6-Sulfatase Deficiency

  • Morquio Syndrome A

  • Mucopolysaccharidosis Iva

  • Mucopolysaccharidosis Type Iva

  • Mpsiva

  • Morquio Disease Type A

  • Mucopolysaccharidosis Type 4a

  • N-Acetylgalactosamine-6-Sulfate Sulfatase Deficiency

  • Morquio Syndrome Type A

  • Mps 4a

  • Morquio Disease, Type A

  • Mucopolysaccharidosis 4a

  • Morquio'S Syndrome A

  • Mps Iv A

  • Mucopolysaccharidosis Iv

  • Mucopolysaccharidosis, Mps-Iv-A
Kbg Syndrome

  • KBGS

  • Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies

  • Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies

  • Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies

  • Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome

  • Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Spondyloepiphyseal Dysplasia Tarda, X-Linked

  • Spondyloepiphyseal Dysplasia Tarda

  • X-Linked Spondyloepiphyseal Dysplasia Tarda

  • SEDT

  • Sed Tarda, X-Linked

  • Spondyloepiphyseal Dysplasia, Late

  • Spondyloepiphyseal Dysplasia Tarda X-Linked

  • Sed

  • X Linked Spondyloepiphyseal Dysplasia Tarda

  • X-Linked Spondyloepiphyseal Dysplasia

  • Late Onset Spondyloepiphyseal Dysplasia

  • Sed Tarda

  • X-Linked Sed

  • X-Linked Sedt

  • Dysplasia, Spondyloepiphyseal, Tarda

  • Spondyloepiphyseal Dysplasia
Neu-Laxova Syndrome 2

  • NLS2
Autosomal Recessive Intellectual Developmental Disorder

  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14989 TRAPPC2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRAPPC2L RGD RGD:1304906
Bos taurus TRAPPC2L VGNC VGNC:36287
Mus musculus TRAPPC2L MGD MGI:1916295
Canis familiaris TRAPPC2L VGNC VGNC:47780
Others TRAPPC2L NCBI