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TRAPPC3 - trafficking protein particle complex subunit 3 Gene

Also Known as BET3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27095

About TRAPPC3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,136,572-36,156,053 (from NCBI)

This gene has 10 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 23.9), adrenal (RPKM 19.7) and 25 other tissues.

Summary

This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

TRAPPC3 Products (5)

mRNA	Protein	Name
NM_001270894.2	NP_001257823.1	trafficking protein particle complex subunit 3 isoform 2
NM_001270895.2	NP_001257824.1	trafficking protein particle complex subunit 3 isoform 3
NM_001270896.2	NP_001257825.1	trafficking protein particle complex subunit 3 isoform 3
NM_001270897.2	NP_001257826.1	trafficking protein particle complex subunit 3 isoform 4
NM_014408.5	NP_055223.1	trafficking protein particle complex subunit 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TRAPP complex	IDA IDA: Inferred from direct assay	21525244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC3 Protein Structure

TRAPP

0
100
180 a.a.

Protein Preferred Names	Protein Names
trafficking protein particle complex subunit 3	trafficking protein particle complex 3

TRAPPC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRAPPC3	O43617	TRAPPC2L	Homo sapiens	Q9UL33-2	Y2H Array	32296183
Intra	TRAPPC3	O43617	TRAPPC2L	Homo sapiens	Q9UL33-2	Validated Y2H	32296183
Intra	TRAPPC3	O43617	TRAPPC2L	Homo sapiens	Q9UL33-2	Y2H Prey Pooling	32296183
Intra	TRAPPC3	O43617	TRAPPC2	Homo sapiens	P0DI81-3	Y2H Prey Pooling	32296183
Intra	TRAPPC3	O43617	TRAPPC2	Homo sapiens	P0DI81-3	Validated Y2H	32296183
Intra	TRAPPC3	O43617	TRAPPC2	Homo sapiens	P0DI81-3	Y2H Array	32296183
Intra	TRAPPC3	O43617	TRAPPC13	Homo sapiens	A5PLN9	Anti Tag CoIP	21453443
Intra	TRAPPC3	O43617	TRAPPC5	Homo sapiens	Q8IUR0	Y2H Prey Pooling	32296183
Intra	TRAPPC3	O43617	TRAPPC5	Homo sapiens	Q8IUR0	Validated Y2H	32296183
Intra	TRAPPC3	O43617	TRAPPC5	Homo sapiens	Q8IUR0	Y2H Array	32296183
Intra	TRAPPC3	O43617	TRAPPC6B	Homo sapiens	Q86SZ2	Anti Bait CoIP	18930054
Intra	TRAPPC3	O43617	TRAPPC6B	Homo sapiens	Q86SZ2	Anti Tag CoIP	16908848
Intra	TRAPPC3	O43617	TRAPPC1	Homo sapiens	Q9Y5R8	Y2H Array	32296183
Intra	TRAPPC3	O43617	TRAPPC1	Homo sapiens	Q9Y5R8	Y2H Prey Pooling	32296183
Intra	TRAPPC3	O43617	TRAPPC1	Homo sapiens	Q9Y5R8	Validated Y2H	32296183
Intra	TRAPPC3	O43617	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956
Intra	TRAPPC3	O43617	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	25416956
Intra	TRAPPC3	O43617	TRAPPC6A	Homo sapiens	O75865	Y2H Pooling	16189514
Intra	TRAPPC3	O43617	TRAPPC6A	Homo sapiens	O75865	Y2H Prey Pooling	25416956
Intra	TRAPPC3	O43617	TRAPPC6A	Homo sapiens	O75865	Validated Y2H	25416956
Intra	TRAPPC3	O43617	TRAPPC6A	Homo sapiens	O75865	Y2H Array	25416956
Intra	TRAPPC3	O43617	TRAPPC6A	Homo sapiens	O75865	Anti Bait CoIP	18930054
Intra	TRAPPC3	O43617	TRAPPC2L	Homo sapiens	Q9UL33	Y2H Pooling	16189514
Intra	TRAPPC3	O43617	TRAPPC2L	Homo sapiens	Q9UL33	Y2H Prey Pooling	25416956
Intra	TRAPPC3	O43617	TRAPPC6A	Homo sapiens	O75865-2	Anti Bait CoIP	18930054
Intra	TRAPPC3	O43617	TRAPPC6A	Homo sapiens	O75865-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spondyloepiphyseal Dysplasia Tarda, X-Linked	Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Tarda SEDT Sed Tarda, X-Linked Spondyloepiphyseal Dysplasia, Late Spondyloepiphyseal Dysplasia Tarda X-Linked Sed X Linked Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Late Onset Spondyloepiphyseal Dysplasia Sed Tarda X-Linked Sed X-Linked Sedt Dysplasia, Spondyloepiphyseal, Tarda Spondyloepiphyseal Dysplasia
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Celery Allergy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14990	TRAPPC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRAPPC3	RGD	RGD:1309135
Mus musculus	TRAPPC3	MGD	MGI:1351486
Felis catus	TRAPPC3	VGNC	VGNC:107683
Canis familiaris	TRAPPC3	VGNC	VGNC:47781
Macaca mulatta	TRAPPC3	VGNC	VGNC:79210
Bos taurus	TRAPPC3	VGNC	VGNC:36288
Others	TRAPPC3	NCBI