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TRAPPC8 - trafficking protein particle complex subunit 8 Gene

Also Known as GSG1; TRS85; HsT2706; KIAA1012

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22878

About TRAPPC8

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:31,829,197-31,943,128 (from NCBI)

This gene has 13 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in testis (RPKM 23.5), thyroid (RPKM 10.8) and 25 other tissues.

Summary

Involved in Golgi organization. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022]

TRAPPC8 Products (1)

mRNA	Protein	Name
NM_014939.5	NP_055754.3	trafficking protein particle complex subunit 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21453443	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	21525244	GOA
involved in collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	32095531	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TRAPP complex	IDA IDA: Inferred from direct assay	21525244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC8 Protein Structure

TRAPPC-Trs85

0
300
600
900
1200
1435 a.a.

Protein Preferred Names	Protein Names
trafficking protein particle complex subunit 8	general sporulation gene 1 homolog

TRAPPC8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRAPPC8	Q9Y2L5	TRAPPC13	Homo sapiens	A5PLN9	Anti Tag CoIP	21453443
Intra	TRAPPC8	Q9Y2L5	TRAPPC3	Homo sapiens	O43617	Anti Tag CoIP	21453443

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spondyloepiphyseal Dysplasia Tarda, X-Linked	Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Tarda SEDT Sed Tarda, X-Linked Spondyloepiphyseal Dysplasia, Late Spondyloepiphyseal Dysplasia Tarda X-Linked Sed X Linked Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Late Onset Spondyloepiphyseal Dysplasia Sed Tarda X-Linked Sed X-Linked Sedt Dysplasia, Spondyloepiphyseal, Tarda Spondyloepiphyseal Dysplasia
Binocular Vision Disease	Simultaneous Visual Perception Without Fusion
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14994	TRAPPC8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRAPPC8	RGD	RGD:1309102
Macaca mulatta	TRAPPC8	VGNC	VGNC:79782
Mus musculus	TRAPPC8	MGD	MGI:2443008
Bos taurus	TRAPPC8	VGNC	VGNC:97321
Felis catus	TRAPPC8	VGNC	VGNC:66516
Canis familiaris	TRAPPC8	VGNC	VGNC:47787
Others	TRAPPC8	NCBI