PPP3CC - protein phosphatase 3 catalytic subunit gamma Gene

Also Known as CNA3; CALNA3; PP2Bgamma

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5533

About PPP3CC

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,441,078-22,541,125 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in testis (RPKM 12.3), lymph node (RPKM 5.3) and 24 other tissues.

Summary

Calcineurin is a calcium-dependent, calmodulin-stimulated protein Phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for Calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

PPP3CC Products (3)

mRNA Protein Name
NM_001243974.2 NP_001230903.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1
NM_001243975.2 NP_001230904.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3
NM_005605.5 NP_005596.2 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables calcium-dependent protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
26429887 GOA
enables calmodulin-dependent protein phosphatase activity IDA
IDA: Inferred from direct assay
19154138 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Références Source
involved in calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
19154138 GOA
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
19154138 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19154138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP3CC Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (80 - 280)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 512 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

  • CAM-PRP catalytic subunit

PPP3CC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PPP3CC P48454 SPATA33 Homo sapiens Q96N06
Validated Y2H
32296183
Intra
PPP3CC P48454 UNC119 Homo sapiens Q13432
Validated Y2H
32296183
Intra
PPP3CC P48454 AMPH Homo sapiens P49418
Y2H Array
25416956
Intra
PPP3CC P48454 AMPH Homo sapiens P49418
Validated Y2H
25416956
Intra
PPP3CC P48454 PPP3R1 Homo sapiens P63098
Anti Tag CoIP
28514442
Intra
PPP3CC P48454 PPP3R1 Homo sapiens P63098
Validated Y2H
32296183
Intra
PPP3CC P48454 PPP3R1 Homo sapiens P63098
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

PPP3CC Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P89890 PP2B-Aγ Antibody (YA9234) WB, IP, ELISA human

Related Diseases

Diseases Alias
Melancholia
Schizophrenia 11

  • Sczd11

  • Schizophrenia Susceptibility Locus, Chromosome 10q-Related
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Schizophrenia 6

  • SCZD6

  • Schizophrenia Susceptibility Locus, Chromosome 8p-Related

  • Schizophrenia, Type 6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11025 PPP3CC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPP3CC VGNC VGNC:69021
Rattus norvegicus PPP3CC RGD RGD:621616
Mus musculus PPP3CC MGD MGI:107162
Canis familiaris PPP3CC VGNC VGNC:44920
Macaca mulatta PPP3CC VGNC VGNC:76383
Bos taurus PPP3CC VGNC VGNC:33267
Others PPP3CC NCBI