NECTIN1 - nectin cell adhesion molecule 1 Gene

Also Known as ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5818

About NECTIN1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,638,098-119,729,200 (from NCBI)

This gene has 7 transcripts (splice variants), 285 orthologues, 14 paralogues and is associated with 7 phenotypes. Biased expression in skin (RPKM 64.2), esophagus (RPKM 38.3) and 8 other tissues.

Summary

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

NECTIN1 Products (3)

mRNA	Protein	Name
NM_002855.5	NP_002846.3	nectin-1 isoform 1 precursor
NM_203285.2	NP_976030.1	nectin-1 isoform 2 precursor
NM_203286.2	NP_976031.1	nectin-1 isoform 3 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12438620	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11277703	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in adherens junction	IDA IDA: Inferred from direct assay	10225955	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECTIN1 Protein Structure

V-set

C2-set_2

Ig_2

0
100
200
300
400
517 a.a.

Protein Preferred Names	Protein Names
nectin-1	ectodermal dysplasia 4 (Margarita Island type)

NECTIN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	NECTIN1	Q15223	NECTIN4	Homo sapiens	Q96NY8	Protein Array	21982860
Intra	NECTIN1	Q15223	NECTIN4	Homo sapiens	Q96NY8	SPR	22902367
Intra	NECTIN1	Q15223	NECTIN4	Homo sapiens	Q96NY8	Solution Sedimentation	22902367
Intra	NECTIN1	Q15223	NECTIN3	Homo sapiens	Q9NQS3	Protein Array	21982860
Intra	NECTIN1	Q15223	NECTIN1	Homo sapiens	Q15223	Protein Array	21982860
Intra	NECTIN1	Q15223	NECTIN1	Homo sapiens	Q15223	FACS	12011057
Intra	NECTIN1	Q15223	NECTIN1	Homo sapiens	Q15223	Solution Sedimentation	22902367
Intra	NECTIN1	Q15223	NECTIN4	Homo sapiens	Q96NY8	FACS	12011057
Intra	NECTIN1	Q15223	NECTIN1	Homo sapiens	Q15223	X-Ray Diffraction	22902367
Intra	NECTIN1	Q15223	NECTIN1	Homo sapiens	Q15223	SPR	22902367
Intra	NECTIN1	Q15223	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NECTIN1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70494	Nectin-1 Protein, Human (HEK293, His)	Q15223-1 (Q31-T334)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78179	Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q15223-1 (Q31-T334)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78494	Nectin-1 Protein, Human (HEK293, His-Avi)	Q15223-1 (Q31-T334)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome	Orofacial Cleft 7 Zlotogora-Ogur Syndrome CLPED1 Ectodermal Dysplasia, Margarita Island Type Ed4 Cleft Lip-Palate-Ectodermal Dysplasia Syndrome Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate Ectodermal Dysplasia 4 Ectodermal Dysplasia Margarita Type Ectodermal Dysplasia, Type 4 Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly Margarita Type Of Ectodermal Dysplasia Zlotogora-Zilberman-Tenenbaum Syndrome Ectd4 Ectodermal Dysplasia 4, Hair/Nail Type EDMI Ectodermal Dysplasia Type 4 Margarita Island Ectodermal Dysplasia Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate Non-Syndromic Orofacial Cleft 7 OFC7 Non-Syndromic Cleft Lip/Palate 7 Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Bustos Simosa Pinto Cisternas Syndrome	Zlotogora Syndrome Zlotogora-Ogur Syndrome Clped1 Cleft Lip/Palate-Ectodermal Dysplasia Syndrome Cleft Lip/Palate-Syndactyly-Pili Torti Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome Ectodermal Dysplasia, Cleft Lip And Palate, Intellectual Disability, And Syndactyly Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate Zlotogora-Zilberman-Tenenbaum Syndrome Autosomal Recessive Ectodermal Dysplasia Ed4 Ectodermal Dysplasia Margarita Island Type Ectodermal Dysplasia Type 4
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Cleft Lip/Palate	Cleft Lip And Palate Alveolar Cleft Lip And Palate Cleft Lip-Alveolus-Palate Syndrome Flp
Cleft Lip	Cheiloschisis Labium Leporinum Cleft Lip, Unilateral, Complete Complete Unilateral Cleft Lip Hare Lip Congenital Fissure Of Lip Isolated Cleft Lip Cleft Lip Without Cleft Palate Cleft Lip Without Cleft Palate, Unilateral Isolated Cleft Lip, Unilateral Cleft Lip Without Cleft Palate, Bilateral Isolated Cleft Lip, Bilateral
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Isolated Cleft Lip
Cleft Lip And Alveolus
Cleft Lip With Or Without Cleft Palate	Tessier Cleft Number 1,2
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Herpetic Whitlow	Herpetic Felon
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Acute Retinal Necrosis Syndrome	Acute Retinal Necrosis Retinal Necrosis Syndrome, Acute
Non-Invasive Bladder Urothelial Carcinoma	Stage 0 Bladder Urothelial Carcinoma
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Orofacial Cleft	Cleft, Orofacial
Pompholyx	Dyshidrosis Vesicular Eczema Of Hands And/Or Feet Cheiropompholyx Dyshydrotic Eczema Eczema, Dyshidrotic Vesicular Hand Eczema
Popliteal Pterygium Syndrome	PPS Faciogenitopopliteal Syndrome Facio-Genito-Popliteal Syndrome Popliteal Web Syndrome Autosomal Dominant Popliteal Pterygium Syndrome Cleft Lip/Palate, Paramedian Mucous Cysts Of The Lower Lip, Popliteal Pterygium, Digital And Genital Anomalies Popliteal Pterygium Syndrome 1 Cleft Lip/Palate Paramedian Mucous Cysts Of The Lower Lip Popliteal Pterygium Digital And Genital Anomalies Popliteal Pterygium
Van Der Woude Syndrome	Lip-Pit Syndrome Vws Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip Vdws Lps Lip Pit Syndrome Cleft Lip/Palate With Mucous Cysts Of Lower Lip Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments
Clouston Syndrome	Ectodermal Dysplasia 2, Clouston Type Hidrotic Ectodermal Dysplasia ECTD2 Clouston'S Hidrotic Ectodermal Dysplasia Hidrotic Ectodermal Dysplasia Syndrome Clouston Hidrotic Ectodermal Dysplasia Clouston'S Syndrome Ed2 Ectodermal Dysplasia, Hidrotic Hed2 Ectodermal Dysplasia Ectodermal Dysplasia, Hidrotic, Autosomal Dominant Ectodermal Dysplasia, Hidrotic, 2, Formerly Hed2, Formerly Autosomal Dominant Hidrotic Ectodermal Dysplasia Hed Hidrotic Ectodermal Dysplasia, Autosomal Dominant Hidrotic Ectodermal Dysplasia 2 Ectodermal Dysplasia 2 Hidrotic Ectodermal Dysplasia Hidrotic Autosomal Dominant Dysplasia, Ectodermal, Hidrotic
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked	Christ-Siemens-Touraine Syndrome XHED Ectodermal Dysplasia 1 Xlhed Ed1 Cst Syndrome Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked Ectd1 Ectodermal Dysplasia, Anhidrotic, X-Linked Eda Eda1 Hed1 Ectodermal Dysplasia 1, Anhidrotic X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia Hypohidrotic X-Linked Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, 1 Hypohidrotic Ectodermal Dysplasia, X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia X-Linked Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked Ectodermal Dysplasia Anhidrotic
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09174	NECTIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20215	Nectin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26721	Nectin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NECTIN1	RGD	RGD:620791
Macaca mulatta	NECTIN1	VGNC	VGNC:82196
Mus musculus	NECTIN1	MGD	MGI:1926483
Canis familiaris	NECTIN1	VGNC	VGNC:43718
Bos taurus	NECTIN1	VGNC	VGNC:54888
Felis catus	NECTIN1	VGNC	VGNC:69187
Others	NECTIN1	NCBI