PIWIL1 - piwi like RNA-mediated gene silencing 1 Gene

Also Known as HIWI; MIWI; PIWI; CT80.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9271

About PIWIL1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,337,887-130,426,260 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 216 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 57.0).

Summary

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

PIWIL1 Products (2)

mRNA Protein Name
NM_001190971.2 NP_001177900.1 piwi-like protein 1 isoform 2
NM_004764.5 NP_004755.2 piwi-like protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables piRNA binding IDA
IDA: Inferred from direct assay
28552346 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14749716 GOA
Biological Process GO Annotation Evidence Références Source
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
28552346 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIWIL1 Protein Structure

GAGE

GAGE: GAGE protein (1 - 106)

PAZ

PAZ: PAZ domain (278 - 413)

Piwi

Piwi: Piwi domain (556 - 847)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 861 a.a.
Protein Preferred Names Protein Names

piwi-like protein 1

  • piwi homolog

PIWIL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PIWIL1 Q96J94 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
PIWIL1 Q96J94 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
PIWIL1 Q96J94 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
PIWIL1 Q96J94 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
PIWIL1 Q96J94 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
PIWIL1 Q96J94 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

PIWIL1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81806 PIWIL1 Antibody (YA1551) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Infertility
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Hyperoxaluria, Primary, Type I

  • Primary Hyperoxaluria Type 1

  • HP1

  • Glycolic Aciduria

  • Alanine-Glyoxylate Aminotransferase Deficiency

  • Hepatic Agt Deficiency

  • Oxalosis I

  • Primary Hyperoxaluria, Type I

  • Serine:Pyruvate Aminotransferase Deficiency

  • Hyperoxaluria, Primary, Type 1

  • Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

  • Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

  • Serine Pyruvate Aminotransferase Deficiency

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Oxalosis 1

  • Hyperoxaluria Primary 1

  • Hyperoxaluria Primary Type I

  • Ph1

  • Primary Hyperoxaluria Type I

  • Oxalosis Type 1

  • 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

  • Hyperoxaluria

  • Hyperoxaluria, Primary

  • Oxalosis

  • Primary Oxalosis

  • Congenital Oxaluria

  • D-Glycerate Dehydrogenase Deficiency

  • Glyceric Aciduria

  • Glycolic Aciduria

  • Hepatic Agt Deficiency

  • Oxaluria, Primary

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Primary Oxaluria

  • Hyperoxaluria Primary

  • Primary Hyperoxaluria Type 2

  • Primary Hyperoxaluria, Type I
Cartilage-Hair Hypoplasia

  • Metaphyseal Chondrodysplasia, Mckusick Type

  • CHH

  • Mckusick Type Metaphyseal Chondrodysplasia

  • Metaphyseal Dysplasia Without Hypotrichosis

  • Cartilage Hair Hypoplasia Like Syndrome

  • Metaphyseal Chondrodysplasia Mckusick Type

  • Chhv

  • Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

  • Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

  • Cartilage-Hair Syndrome

  • Mckusick'S Metaphyseal Chondrodysplasia Syndrome

  • Metaphyseal Chondrodysplasia, Recessive Type

  • Autosomal Recessive Metaphyseal Chondrodysplasia
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS10584 PIWIL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PIWIL1 VGNC VGNC:80463
Rattus norvegicus PIWIL1 RGD RGD:1306980
Bos taurus PIWIL1 VGNC VGNC:32927
Mus musculus PIWIL1 MGD MGI:1928897
Macaca mulatta PIWIL1 VGNC VGNC:81501
Canis familiaris PIWIL1 VGNC VGNC:44592
Others PIWIL1 NCBI