Glochidiol
Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity.
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- CAS No.: 6610-56-6
- Formule: C30H50O2
- Masse moléculaire:442.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 2.76 μΜ (tubulin polymerization)[1]
Glochidiol (1-8 μM; 48 h) shows potent antiproliferative activity against lung cancer cell lines in a concentration-dependent manner[1].
Glochidiol interacts with tubulin by targeting the colchicine binding site[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6
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Concentration:1, 2, 4 and 8 μM
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Incubation Time:48 h
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Result:Showed potent antiproliferative activity against lung cancer cell lines NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 with IC50 values of 4.12 µM, 2.01 µM, 7.53 µM, 1.62 µM, 4.79 µM, 7.69 µM, 2.36 µM, 6.07 µM and 2.10 µM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice bearing HCC-44 xenografts[1]
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Dosage:60 mg/kg/day
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Administration:Intragastric administration for a period of 21 days
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Result:Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney.
Chemical Information
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CAS No. 6610-56-6
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Masse moléculaire 442.72
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Formule C30H50O2
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SMILES
C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4(C)[C@]3([H])[C@@H](CC4)C(C)=C)C)([H])[C@@]5([C@@](C(C)([C@H](O)C[C@H]5O)C)([H])CC1)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glochidiol Related Classifications
HY-N3950 Related Classifications
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