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Cat. No.: HY-117086

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GSK065

GSK065 is a KMO inhibitor with an IC₅₀ of 2.5 nM and a K_i of 0.05 nM. GSK065 prevents the effective binding of NADPH to its substrate. GSK065 can be used in studies related to multiple organ dysfunction syndrome associated with acute pancreatitis.

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CAS No.: 1953156-61-0
Formule: C₁₇H₁₅ClN₂O₄
Masse moléculaire:346.77

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSK065 Chemical Structure

CAS No.: 1953156-61-0

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

In Vitro

GSK065 does not stimulate human KMO to produce hydrogen peroxide; instead, it reduces peroxide levels below basal levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1953156-61-0
Masse moléculaire 346.77
Formule C₁₇H₁₅ClN₂O₄
SMILES

C(CC(O)=O)C=1C=2C(=CC(O[C@H](C)C3=CC=CC=N3)=C(Cl)C2)ON1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hutchinson JP, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nature communications. 2017 Jun 12;8:15827. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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