Cat. No.: HY-78883

ON 01500

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ON 01500 is a tubulin inhibitor with a K_d of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers.

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Pureté: 99.07%
CAS No.: 592542-50-2
Formule: C₁₉H₂₃NO₆S
Masse moléculaire:393.45

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ON 01500 Chemical Structure

CAS No.: 592542-50-2

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

ON 01500 is a tubulin inhibitor with a K_d of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
2008	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human 2008 cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against human 2008 cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
A549	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human A549 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human A549 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
AGS	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human AGS cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human AGS cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
BT-20	IC₅₀	0.03 μM Compound: 8p	Cytotoxicity against human BT20 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human BT20 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
BT-474	IC₅₀	0.002 μM Compound: 8p	Cytotoxicity against human BT474 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human BT474 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
CCRF-CEM	IC₅₀	0.01 μM Compound: 8p	Cytotoxicity against human CEM cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against human CEM cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
CEM/C2	IC₅₀	0.01 μM Compound: 8p	Cytotoxicity against multidrug-resistant human CEM/C2 cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against multidrug-resistant human CEM/C2 cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
COLO 205	IC₅₀	0.005 μM Compound: 8p	Cytotoxicity against human COLO205 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human COLO205 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
COLO 320	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human COLO320 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human COLO320 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
Daudi	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human Daudi cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human Daudi cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
DLD-1	IC₅₀	0.005 μM Compound: 8p	Cytotoxicity against human DLD1 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human DLD1 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
DU-145	IC₅₀	0.004 μM Compound: 8p	Cytotoxicity against human DU145 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human DU145 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
Granta-519	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human GRANTA-519 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human GRANTA-519 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HCT-116	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human HCT116 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HCT116 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HCT-15	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human HCT15 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HCT15 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
K562	IC₅₀	0.0025 μM Compound: 8p	Cytotoxicity against human K562 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human K562 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
LP-1	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human LP-1 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human LP-1 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MCF7	IC₅₀	0.001 μM Compound: 8p	Cytotoxicity against human MCF7 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MCF7 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MES-SA	IC₅₀	0.004 μM Compound: 8p	Cytotoxicity against human MES-SA cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against human MES-SA cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
MES-SA/Dx5	IC₅₀	0.004 μM Compound: 8p	Cytotoxicity against multidrug-resistant human MES-SA/Dx5 cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against multidrug-resistant human MES-SA/Dx5 cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
MIA PaCa-2	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human MIAPaCa2 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MIAPaCa2 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MOLT-4	IC₅₀	0.004 μM Compound: 8p	Cytotoxicity against human MOLT4 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MOLT4 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NAMALVA	IC₅₀	0.005 μM Compound: 8p	Cytotoxicity against human NAMALWA cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NAMALWA cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H157	IC₅₀	0.004 μM Compound: 8p	Cytotoxicity against human NCI-H157 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-H157 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H187	IC₅₀	0.004 μM Compound: 8p	Cytotoxicity against human NCI-H187 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-H187 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H1975	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human NCI-H1975 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-H1975 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H417	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human NCI-N417 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-N417 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
OPM-2	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human OPM2 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human OPM2 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
OVCAR-3	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human OVCAR3 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human OVCAR3 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
PC-3	IC₅₀	0.006 μM Compound: 8p	Cytotoxicity against human PC3 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human PC3 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
Raji	IC₅₀	0.002 μM Compound: 8p	Cytotoxicity against human Raji cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human Raji cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
SK-BR-3	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human SKBR3 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human SKBR3 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
SW480	IC₅₀	0.005 μM Compound: 8p	Cytotoxicity against human SW480 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human SW480 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
T47D	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human T47D cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human T47D cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
U-266	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human U266 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human U266 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
U-87MG ATCC	IC₅₀	0.003 μM Compound: 8p	Cytotoxicity against human U87 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human U87 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]

In Vitro

ON 01500 (1 μM) completely inhibits tubulin polymerization in MAP-rich tubulin samples^[1].
ON 01500 (7-15 nM, 3-5 days) sensitizes cells to knockdown of TACC3 or overexpression of KIF2C and protects cells from overexpression of TACC3 or knockdown of KIF2C, with high toxicity^[2].
ON 01500 (10 nM, 3-7 days) induces enrichment of L240F TUBB-expressing (mCherry-positive) K562 cells relative to wild-type cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 592542-50-2
Appearance Solid
Masse moléculaire 393.45
Formule C₁₉H₂₃NO₆S
SMILES

NC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Baker SJ, et al. A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent. Mol Cell. 2020 Jul 2;79(1):180-190.e4. [Content Brief]

[2]. Jost, Marco et al. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Molecular Cell, Volume 79, Issue 1, 191 - 198.e3

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ON 01500

Cell Cycle/DNA Damage Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Cytoskeleton Compound Library

Anti-Lung Cancer Compound Library

Protein-protein Interaction Inhibitor Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Calculators

Help & FAQs

ON 01500

Cell Cycle/DNA Damage Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Cytoskeleton Compound Library

Anti-Lung Cancer Compound Library

Protein-protein Interaction Inhibitor Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Calculators

Help & FAQs

ON 01500 Related Classifications

HY-78883 Related Classifications