Parconazole
Parconazole is an orally active imidazole derivative and antifungal (fungal) agent. Parconazole inhibits sterol 14α-demethylase (CYP51) and Δ22-desaturase (CYP61), disrupting fungal Ergosterol (HY-N0181) biosynthesis by reducing the availability of ergosterol and promoting the accumulation of 14-methyl sterols. Parconazole exhibits in vitro antifungal activity against dermatophytes, Candida species, Blastomyces dermatitidis yeast, piedraia, and actinomycetes. Parconazole can be used in the study of fungal infections.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 61400-59-7
- Formule: C17H16Cl2N2O3
- Masse moléculaire:367.23
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
In Vitro
Parconazole (0.01-100 mg/L; 30-2000 nM) inhibits the in vitro growth of diverse fungi, with 50% inhibition of Candida albicans growth occurring at 30 nM in CYG medium and complete inhibition of dermatophyte growth occurring at 1-10 mg/L in Sabouraud liquid medium[1].
Parconazole selectively inhibits Candida albicans cytochrome P450, with far higher affinity for the fungal enzyme than for three different mammalian cytochrome P450 isoforms[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:guinea fowl[1]
-
Dosage:13 mg/kg
-
Administration:p.o.; single administration
-
Result:Reached a peak plasma concentration of 2.28 mg/L at 2 h, and is mainly enriched in the crop and skin.
Chemical Information
-
CAS No. 61400-59-7
-
Masse moléculaire 367.23
-
Formule C17H16Cl2N2O3
-
SMILES
C([C@]1(O[C@@H](COCC#C)CO1)C2=C(Cl)C=C(Cl)C=C2)N3C=CN=C3
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Parconazole Related Classifications
HY-187673 Related Classifications
Powered by Bioz