The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives

  • Planta Med. 1990 Aug;56(4):383-5. doi: 10.1055/s-2006-960989.
D J Pan  1 ,  Z L Li ,  C Q Hu ,  K Chen ,  J J Chang ,  K H Lee
Affiliations
  • 1. Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
PMID: 2236294 DOI: 10.1055/s-2006-960989
Abstract

Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human Cancer cell line panels is discussed.

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