Remikiren
Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension.
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- CAS No.: 126222-34-2
- Formule: C33H50N4O6S
- Masse moléculaire:630.84
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50:0.7 nM (human pure renin), 0.8 nM (plasma renin of human)[1].
Remikiren (0-10 nM; 1-3 h) displays a considerable specificity to inhibit renin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human pure renin, plasma renin of human, marmoset, squirrel monkey
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Concentration:0-10 nM
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Incubation Time:1-3 h
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Result:Inhibited human pure renin and plasma renin of human, marmoset, squirrel monkey with IC50 values of 0.7, 0.8, 1.0 and 1.7 nM, respectively.
Remikiren (3 mg/kg; p.o.; single) shows the duration of blood pressure decrease more than 24 h in sodium-depleted marmosets[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Marmosets and squirrel monkeys (sodium-depleted)[1].
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Dosage:0.1, 0.3, 1, 3, 10 mg/kg
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Administration:Oral administration; single.
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Result:Decreased mean arterial pressure (MAP) by 20-25 mm Hg when at 0.1 mg/kg.
Reached the maximal decrease (30 mm Hg) of MAP with 1 mg/kg in marmosets.
Decreasesd 35 mm Hg blood pressure with 3-10 mg/kg in squirrel monkeys.
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Animal Model:Marmosets (sodium-depleted)[1].
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Dosage:3 mg/kg
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Administration:Oral administration; single.
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Result:Showed MAP fell by 30 mm Hg, which lasting more than 24 h.
Chemical Information
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CAS No. 126222-34-2
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Masse moléculaire 630.84
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Formule C33H50N4O6S
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SMILES
CC(C)(C)S(C[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CN=CN2)C(N[C@H]([C@@H](O)[C@H](C3CC3)O)CC4CCCCC4)=O)=O)(=O)=O
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Synonyms
Ro 42-5892; Ro 42-5892/001
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Remikiren Related Classifications
HY-A0184 Related Classifications
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