2. GPCR/G Protein Immunology/Inflammation
  3. G protein-coupled Bile Acid Receptor 1 MHC
  4. Cholic acid 7-sulfate

Cholic acid 7-sulfate  (Synonyms: 7-Sulfocholic acid)

製品番号: HY-126855 純度: 99.92%
COA 取扱説明書 Technical Support

Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Cholic acid 7-sulfate

Cholic acid 7-sulfate 構造式

CAS 番号 : 60320-05-0

容量 価格（税別） 在庫状況 数量
5 mg $430 在庫あり
10 mg $710 在庫あり
25 mg $1420 在庫あり
50 mg $2300 在庫あり
100 mg $3700 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Cholic acid 7-sulfate:

Cholic acid 7-sulfate 関連抗体

Top Publications Citing Use of Products

MHC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
MHC I MHC II

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation[1][2].

IC50 & Target

TGR[1]
体外実験

Cholic acid 7-sulfate activates human TGR5 in a dose-dependent manner and induces GLP-1 secretion from NCI-H716 cells (EC50=0.17 μM), and this effect can be inhibited by TGR5 siRNA knockdown[1].
Cholic acid 7-sulfate (1 mM; 6 d) promotes MAIT cell survival and induces CXCR4 and IL7R expression when stimulated with human PBMCs, without causing cell proliferation or CD69 upregulation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cholic acid 7-sulfate 関連抗体

Cell Viability Assay[1]

Cell Line: PBMCs
Concentration: 1 mM
Incubation Time: 6 days
Result: Promotes MAIT cell survival.
体内実験

Cholic acid 7-sulfate (1 mg; enteral administration; single dose; 15 min) increases circulating GLP-1 levels, decreases blood glucose, and increases insulin in diet-induced obese (DIO) mice, while inducing colonic Tgr5 gene expression[1]. Cholic acid 7-sulfate (100 mg/kg; oral gavage; single dose; 5 h) improves glucose tolerance and increases circulating GLP-1 in DIO mice, and the glucose clearance effect is dependent on TGR5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

488.63

分子式

C24H40O8S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](OS(=O)(O)=O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (204.65 mM)

DMF : 1 mg/mL (2.05 mM; Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0465 mL 10.2327 mL 20.4654 mL
5 mM 0.4093 mL 2.0465 mL 4.0931 mL
10 mM 0.2047 mL 1.0233 mL 2.0465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.92%

COA (255 KB) HNMR (203 KB) RP-HPLC (247 KB) MS (80 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / H2O 1 mM 2.0465 mL 10.2327 mL 20.4654 mL 51.1635 mL
H2O 5 mM 0.4093 mL 2.0465 mL 4.0931 mL 10.2327 mL
10 mM 0.2047 mL 1.0233 mL 2.0465 mL 5.1163 mL
15 mM 0.1364 mL 0.6822 mL 1.3644 mL 3.4109 mL
20 mM 0.1023 mL 0.5116 mL 1.0233 mL 2.5582 mL
25 mM 0.0819 mL 0.4093 mL 0.8186 mL 2.0465 mL
30 mM 0.0682 mL 0.3411 mL 0.6822 mL 1.7054 mL
40 mM 0.0512 mL 0.2558 mL 0.5116 mL 1.2791 mL
50 mM 0.0409 mL 0.2047 mL 0.4093 mL 1.0233 mL
60 mM 0.0341 mL 0.1705 mL 0.3411 mL 0.8527 mL
80 mM 0.0256 mL 0.1279 mL 0.2558 mL 0.6395 mL
100 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5116 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Cholic acid 7-sulfate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholic acid 7-sulfate60320-05-07-Sulfocholic acidG protein-coupled Bile Acid Receptor 1MHCG-protein coupled receptor 19GPCR19TGR5GPBAR1Major Histocompatibility ComplexTgr5GLP-1Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Cholic acid 7-sulfate
製品番号:
HY-126855
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.