1. Colistin methanesulfonate sodium salt

Colistin methanesulfonate sodium salt 

Cat. No.: HY-A0214 Purity: ≥99.0%
COA Handling Instructions

Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa).

For research use only. We do not sell to patients.

Colistin methanesulfonate sodium salt Chemical Structure

Colistin methanesulfonate sodium salt Chemical Structure

CAS No. : 8068-28-8

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Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa)[1].

In Vitro

Colistin methanesulfonate is less bactericidal than colistin at the same multiples of the MIC. Colistin and colistin methanesulfonate are both unequal mixtures of the salts of two components, colistins A and B (1), which may well have different in vitro activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.




White to off-white


[Colistin methanesulfonate (sodium salt)]


Room temperature in continental US; may vary elsewhere.


4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Colistin methanesulfonate sodium salt
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