CVT-2738 (Synonyms: RS-94287)

Cat. No.: HY-W009512 Purity: 99.81%: Data Sheet
COA

SDS
Handling Instructions
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CVT-2738 is an orally active metabolite of Ranolazine (HY-B0280). CVT-2738 has a protective effect against Isoprenaline (HY-108353)-induced myocardial ischemia in mice. CVT-2738 can be used in myocardial ischemia research.

For research use only. We do not sell to patients.

CVT-2738 Chemical Structure

CAS No. : 5294-61-1

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Free Sample (0.1 - 0.2 mg)	Apply Now
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	In-stock	Estimated Time of Arrival: December 31
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Other Forms of CVT-2738:

CVT-2738-d₈ Get quote
CVT-2738-d₆ Get quote
CVT-2738 (Standard) Get quote

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Description

In Vivo

CVT-2738 (100 mg/kg, i.g., single dose) has an ameliorative/protective effect in the Isoprenaline (HY-108353)-induced myocardial ischemia model in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Isoprenaline (0.5 mL/20 g, s.c.)-induced myocardial ischemia injury Kunming mice (half male and half female weighing 20-30 g) model^[1]
Dosage:	100 mg/kg
Administration:	i.g., once
Result:	Inhibited the elevation of T-waves, comparing with Ranolazine, no remarkable difference was found. Inhibited the extension of R-R interval, but less potent than that of Ranolazine. Had very remarkable effect on cardiac index, but had no significant inhibition of the elevation of myocardial water content.

Molecular Weight

247.34

Formula

C₁₄H₂₁N₃O

CAS No.

5294-61-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (40.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0430 mL	20.2151 mL	40.4302 mL
5 mM	0.8086 mL	4.0430 mL	8.0860 mL
10 mM	0.4043 mL	2.0215 mL	4.0430 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (4.04 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (4.04 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1 mg/mL (4.04 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (245 KB) HNMR (119 KB) RP-HPLC (190 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Yao Z, et al. Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities. Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1218-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0430 mL	20.2151 mL	40.4302 mL	101.0754 mL
	5 mM	0.8086 mL	4.0430 mL	8.0860 mL	20.2151 mL
	10 mM	0.4043 mL	2.0215 mL	4.0430 mL	10.1075 mL
	15 mM	0.2695 mL	1.3477 mL	2.6953 mL	6.7384 mL
	20 mM	0.2022 mL	1.0108 mL	2.0215 mL	5.0538 mL
	25 mM	0.1617 mL	0.8086 mL	1.6172 mL	4.0430 mL
	30 mM	0.1348 mL	0.6738 mL	1.3477 mL	3.3692 mL
	40 mM	0.1011 mL	0.5054 mL	1.0108 mL	2.5269 mL

CVT-2738 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CVT-27385294-61-1RS-94287CVT2738CVT 2738RS94287RS 94287Drug Metabolitemyocardial ischemiaRanolazineIsoprenaline-induced myocardial ischemia injury miceInhibitorinhibitorinhibit

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CVT-2738 (Synonyms: RS-94287)

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