CyPep-1 acetate
Based on 1 Customer Validation
CyPep-1 acetate is a novel cationic lytic peptide with antitumor activity. CyPep-1 acetate is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 acetate has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors.
For research use only. We do not sell to patients.
- Purity : 99.17%
- Formula: C152H265N57O35·xC2HF3O2
- Molecular Weight:3451.09 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
CyPep-1 (0-40 μg/mL; 15-360 min) acetate produces toxicity to tumor cell lines in a dose- and time-dependent manner, with little effect on normal cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T1 murine metastatic breast cancer cells treated female BALB/c mice (average age 12625 days; average weight 23.8g)[1]
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Dosage:1200 µg
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Administration:Intratumoural injection; single dose
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Result:Did not cause any signs of discomfort, pain or toxicity.
Significantly reduced tumour growth and caused massive necrosis of the tumours.
Prolonged the median survival time of mice.
Chemical Information
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Appearance Solid
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Molecular Weight 3451.09 (free base)
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Formula C152H265N57O35·xC2HF3O2
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Color White to off-white
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SMILES
O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CC=C(C=C3)O)N.CC(O)=O.[x]
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Sequence
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Lys-Thr-Leu-Arg-Val-Ala-Lys-Ala-Ile-Tyr-Lys-Arg-Tyr-Ile-Glu
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Sequence Shortening
YGRKKRRQRRRGKTLRVAKAIYKRYIE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 25 mg/mL (Need ultrasonic)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (294 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
CyPep-1 acetate Related Classifications
HY-P10841A Related Classifications
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