Art. -Nr.: HY-131553

D-α-Tocopherol Succinate

(Synonyms: Vitamin E succinate)

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.

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Reinheit: 98.0%
CAS. Nr.: 4345-03-3
Formel: C₃₃H₅₄O₅
Molecular Weight:530.78

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

D-α-Tocopherol Succinate Chemical Structure

CAS. Nr.: 4345-03-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	10 μM Compound: 1, VES	Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA	[PMID: 19708661]
HCT-116	IC₅₀	52.3 μM Compound: alpha-TOS	Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay	10.1007/s00044-011-9801-3
HepG2	IC₅₀	245 μM Compound: alpha-TOS	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
HepG2	IC₅₀	55 μM Compound: alpha-TOS	Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay	10.1007/s00044-011-9801-3
MCF7	IC₅₀	>368 μM Compound: alpha-TO-succinate	Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay	[PMID: 9873556]
MCF7	IC₅₀	57 μM Compound: alpha-TOS	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
MT4	IC₅₀	66 μM Compound: alpha-TOS	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
RPMI-8226	IC₅₀	63 μM Compound: alpha-TOS	Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
U-937	IC₅₀	113 μM Compound: alpha-TOS	Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]

In Vitro

D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells^[1].
D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity^[1].
D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEI-OC1 cell line
Concentration:

1-20 μM
Incubation Time:

24 hours
Result:

Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.

Cell Viability Assay^[1]

Cell Line:

HEI-OC1 cell line
Concentration:

10 μM
Incubation Time:

48 hours
Result:

Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.

Cell Cytotoxicity Assay^[2]

Cell Line:

TC-1 tumor cells
Concentration:

0, 25 and 50 μM
Incubation Time:

18 hours
Result:

Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.

In Vivo

D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells^[2]
Dosage:

1 and 2 mg/kg
Administration:

Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days
Result:

Dreased the tumor volume, especially with a dose of 2 mg/kg.

Chemical Information

CAS. Nr. 4345-03-3
Appearance Solid
Molecular Weight 530.78
Formel C₃₃H₅₄O₅
Color White to off-white
SMILES

CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OC(CCC(O)=O)=O)=C1C)C
Synonyms

Vitamin E succinate
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Adv Sci (Weinh)

Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression. [Abstract]

2023 Aug;10(22):e2206798. PMID: 37330650
Adv Healthc Mater

Cascade-Responsive Nanoprodrug Disrupts Immune-Fibroblast Communications for Potentiated Cancer Mechanoimmunotherapy. [Abstract]

2025 Apr;14(11):e2500176. PMID: 40079115
Hum Reprod

Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing. [Abstract]

2024 Oct 1;39(10):2189-2209. PMID: 39241251

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (471.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8840 mL

9.4201 mL

18.8402 mL

5 mM

0.3768 mL

1.8840 mL

3.7680 mL

10 mM

0.1884 mL

0.9420 mL

1.8840 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14. [Content Brief]

[2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8840 mL	9.4201 mL	18.8402 mL	47.1005 mL
	5 mM	0.3768 mL	1.8840 mL	3.7680 mL	9.4201 mL
	10 mM	0.1884 mL	0.9420 mL	1.8840 mL	4.7100 mL
	15 mM	0.1256 mL	0.6280 mL	1.2560 mL	3.1400 mL
	20 mM	0.0942 mL	0.4710 mL	0.9420 mL	2.3550 mL
	25 mM	0.0754 mL	0.3768 mL	0.7536 mL	1.8840 mL
	30 mM	0.0628 mL	0.3140 mL	0.6280 mL	1.5700 mL
	40 mM	0.0471 mL	0.2355 mL	0.4710 mL	1.1775 mL
	50 mM	0.0377 mL	0.1884 mL	0.3768 mL	0.9420 mL
	60 mM	0.0314 mL	0.1570 mL	0.3140 mL	0.7850 mL
	80 mM	0.0236 mL	0.1178 mL	0.2355 mL	0.5888 mL
	100 mM	0.0188 mL	0.0942 mL	0.1884 mL	0.4710 mL

Keywords

D-α-Tocopherol Succinate

3 Cited Publications

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D-α-Tocopherol Succinate

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Publications Citing Use of MedChemExpress (MCE) D-α-Tocopherol Succinate

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

D-α-Tocopherol Succinate

Antioxidant Compound Library

Human Metabolite Library

Cell Death Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Dietary Supplement Library

Vitamin Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Cosmetic Ingredient Compound Library

Chinese Baijiu Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Publications Citing Use of MedChemExpress (MCE) D-α-Tocopherol Succinate

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

D-α-Tocopherol Succinate Related Classifications

HY-131553 Related Classifications