2. Apoptosis
  3. Apoptosis
  4. D-α-Tocopherol Succinate

D-α-Tocopherol Succinate  (Synonyms: Vitamin E succinate)

Cat. No.: HY-131553 Purity: ≥98.0%
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D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.

For research use only. We do not sell to patients.

D-α-Tocopherol Succinate Chemical Structure

D-α-Tocopherol Succinate Chemical Structure

CAS No. : 4345-03-3

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250 mg USD 75 In-stock
500 mg USD 95 In-stock
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Based on 1 publication(s) in Google Scholar

D-α-Tocopherol Succinate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE D-α-Tocopherol Succinate

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Description

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].

In Vitro

D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1].
D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1].
D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-α-Tocopherol Succinate Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 1-20 μM
Incubation Time: 24 hours
Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.

Cell Viability Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 10 μM
Incubation Time: 48 hours
Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.

Cell Cytotoxicity Assay[2]

Cell Line: TC-1 tumor cells
Concentration: 0, 25 and 50 μM
Incubation Time: 18 hours
Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
In Vivo

D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2]
Dosage: 1 and 2 mg/kg
Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days
Result: Dreased the tumor volume, especially with a dose of 2 mg/kg.
Molecular Weight

530.78

Formula

C33H54O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OC(CCC(O)=O)=O)=C1C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (471.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8840 mL 9.4201 mL 18.8402 mL
5 mM 0.3768 mL 1.8840 mL 3.7680 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8840 mL 9.4201 mL 18.8402 mL 47.1005 mL
5 mM 0.3768 mL 1.8840 mL 3.7680 mL 9.4201 mL
10 mM 0.1884 mL 0.9420 mL 1.8840 mL 4.7100 mL
15 mM 0.1256 mL 0.6280 mL 1.2560 mL 3.1400 mL
20 mM 0.0942 mL 0.4710 mL 0.9420 mL 2.3550 mL
25 mM 0.0754 mL 0.3768 mL 0.7536 mL 1.8840 mL
30 mM 0.0628 mL 0.3140 mL 0.6280 mL 1.5700 mL
40 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1775 mL
50 mM 0.0377 mL 0.1884 mL 0.3768 mL 0.9420 mL
60 mM 0.0314 mL 0.1570 mL 0.3140 mL 0.7850 mL
80 mM 0.0236 mL 0.1178 mL 0.2355 mL 0.5888 mL
100 mM 0.0188 mL 0.0942 mL 0.1884 mL 0.4710 mL
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D-α-Tocopherol Succinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-α-Tocopherol4345-03-3Vitamin EApoptosiscisplatinantioxidantototoxicityROSapoptosisTC-1HEI-OC1caspase-3Inhibitorinhibitorinhibit

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