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DONSON - DNA replication fork stabilization factor DONSON Gene

Also Known as B17; MIMIS; MISSLA; C21orf60

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29980

About DONSON

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,577,551-33,588,684 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and is associated with 4 phenotypes. Broad expression in testis (RPKM 22.3), urinary bladder (RPKM 14.4) and 23 other tissues.

Summary

This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

DONSON Products (1)

mRNA	Protein	Name
NM_017613.4	NP_060083.1	protein downstream neighbor of Son

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28191891	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in mitotic DNA replication checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	28191891	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	28191891	GOA
located in replication fork	IDA IDA: Inferred from direct assay	28191891	GOA
part of replisome	IDA IDA: Inferred from direct assay	28191891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein downstream neighbor of Son	downstream neighbor of SON

DONSON Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DONSON	Q9NYP3	MCM2	Homo sapiens	P49736	Anti Bait CoIP	32769987
Intra	DONSON	Q9NYP3	MCM2	Homo sapiens	P49736	Anti Tag CoIP	32769987
Intra	DONSON	Q9NYP3	GINS1	Homo sapiens	Q14691	Anti Bait CoIP	32769987
Intra	DONSON	Q9NYP3	GINS1	Homo sapiens	Q14691	Anti Tag CoIP	32769987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microcephaly, Short Stature, And Limb Abnormalities	MISSLA Microcephaly-Short Stature-Limb Abnormalities Syndrome Microcephaly, Short Stature, Limb Abnormalities
Microcephaly-Micromelia Syndrome	MIMIS
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Meier-Gorlin Syndrome 5	MGORS5 Meier-Gorlin Syndrome, Type 5
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies	Image Syndrome IMAGE Intrauterine Growth Retardation-Metaphyseal Dysplasia-Adrenal Hypoplasia Congenita-Genital Anomalies Syndrome Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Abnormalities Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Anomalies Image Anomaly Image Association Fetal Growth Retardation Pyle Metaphyseal Dysplasia
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03941	DONSON Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DONSON	VGNC	VGNC:96918
Macaca mulatta	DONSON	VGNC	VGNC:103810
Bos taurus	DONSON	VGNC	VGNC:56216
Rattus norvegicus	DONSON	RGD	RGD:1306823
Mus musculus	DONSON	MGD	MGI:1890621
Others	DONSON	NCBI