RALB - RAS like proto-oncogene B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5899

About RALB

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:120,240,070-120,294,710 (from NCBI)

This gene has 8 transcripts (splice variants), 266 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 28.5), appendix (RPKM 25.0) and 25 other tissues.

Summary

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

RALB Products (2)

mRNA Protein Name
NM_001369400.1 NP_001356329.1 ras-related protein Ral-B
NM_002881.3 NP_002872.1 ras-related protein Ral-B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
enables GDP binding IDA
IDA: Inferred from direct assay
24056301 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
19166349 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
24056301 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
19166349 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7673236 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
24056301 GOA
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
34096503 GOA
involved in positive regulation of protein binding IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in positive regulation of protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in receptor internalization IGI
IGI: Inferred from genetic interaction
34096503 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in midbody IDA
IDA: Inferred from direct assay
18756269 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17875936 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RALB Protein Structure

Ras

Ras: Ras family (16 - 177)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

ras-related protein Ral-B

  • RALB Ras like proto-oncogene B

RALB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RALB P11234 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
RALB P11234 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
RALB P11234 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RALB Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82071 RALB Antibody (YA1816) WB, IP Human, Mouse
HY-P82071A RALB Antibody (YA1816)(PBS only) WB, IP Human, Mouse
HY-P84056 RALB Antibody (YA3753) WB, IHC-P, FC, ELISA Human, Mouse, Monkey
HY-P84056A RALB Antibody (YA3753)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse, Monkey

Related Diseases

Diseases Alias
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-12875 BQU57 Inhibitor 98.47% Unkown
HY-12873 RBC8 Inhibitor 98.0% Unkown
HY-RS11628 RALB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RALB RGD RGD:619852
Macaca mulatta RALB VGNC VGNC:99396
Bos taurus RALB VGNC VGNC:33699
Felis catus RALB VGNC VGNC:69228
Mus musculus RALB MGD MGI:1927244
Canis familiaris RALB VGNC VGNC:45331
Others RALB NCBI