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Art. -Nr.: HY-149982

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IDO1-IN-22

IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC₅₀: 67.4 nM, HeLa hIDO1 IC₅₀: 17.6 nM). IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2126853-16-3
Formel: C₁₂H₁₂BrFN₆O₃
Molecular Weight:387.16

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

IDO1-IN-22 Chemical Structure

CAS. Nr.: 2126853-16-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CT26	IC₅₀	34.9 μM Compound: 3	Cytotoxicity against mouse CT26 cells assessed as cell viability measured after 24 hrs by CCK-8 assay Cytotoxicity against mouse CT26 cells assessed as cell viability measured after 24 hrs by CCK-8 assay	[PMID: 36842272]
HCT-116	IC₅₀	19.6 μM Compound: 3	Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 24 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 24 hrs by CCK-8 assay	[PMID: 36842272]
HeLa	IC₅₀	46.1 μM Compound: 3	Cytotoxicity against human HeLa cells assessed as cell viability measured after 24 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as cell viability measured after 24 hrs by CCK-8 assay	[PMID: 36842272]

Chemical Information

CAS. Nr. 2126853-16-3
Molecular Weight 387.16
Formel C₁₂H₁₂BrFN₆O₃
SMILES

CCNC(NC1=NON=C1/C(NC2=CC=C(C(Br)=C2)F)=N/O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ye K, et al. Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors. Eur J Med Chem. 2023 Mar 15;250:115217. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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