FZD10 - frizzled class receptor 10 Gene

Also Known as Fz10; FzE7; CD350; FZ-10; hFz10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11211

About FZD10

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,162,464-130,165,740 (from NCBI)

This gene has 2 transcripts (splice variants), 190 orthologues and 15 paralogues.

Summary

This gene is a member of the Frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon Cancer. [provided by RefSeq, Jul 2008]

FZD10 Products (1)

mRNA Protein Name
NM_007197.4 NP_009128.1 frizzled-10 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt receptor activity IDA
IDA: Inferred from direct assay
28733458 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15930302 GOA
Biological Process GO Annotation Evidence References Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
28733458 GOA
involved in non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19137009 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
19137009 GOA
acts upstream of regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
19137009 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
18271942 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16007199 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD10 Protein Structure

Fz

Fz: Fz domain (34 - 148)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (218 - 540)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 581 a.a.
Protein Preferred Names Protein Names

frizzled-10

  • frizzled 10, seven transmembrane spanning receptor

FZD10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FZD10 Q9ULW2 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
FZD10 Q9ULW2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
FZD10 Q9ULW2 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
FZD10 Q9ULW2 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
FZD10 Q9ULW2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
FZD10 Q9ULW2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
FZD10 Q9ULW2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
FZD10 Q9ULW2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
FZD10 Q9ULW2 P4HB Homo sapiens P07237
Y2H Prey Pooling
32296183
Intra
FZD10 Q9ULW2 P4HB Homo sapiens P07237
Y2H Array
32296183
Intra
FZD10 Q9ULW2 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Intra
FZD10 Q9ULW2 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Intra
FZD10 Q9ULW2 HILPDA Homo sapiens Q9Y5L2
Anti Bait CoIP
15930302
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD10 Proteins

Cat. No. Product Name Accession Purity
HY-P74146 Frizzled-10/CD350 Protein, Human (HEK293, His) NP_009128.1 (I21-G161) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74147 Frizzled-10/CD350 Protein, Human (HEK293, Fc) NP_009128.1 (I21-G161) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Fallopian Tube Serous Adenocarcinoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Sarcoma, Synovial

  • Synovial Sarcoma

  • Synovialosarcoma

  • Synovial Cell Sarcoma

  • Sarcoma Synovial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05177 FZD10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17505 Fzd10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18359 Fzd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23962 Fzd10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24838 Fzd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99581 Tabituximab barzuxetan (exclude Y90) / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FZD10 RGD RGD:1583825
Canis familiaris FZD10 VGNC VGNC:41029
Felis catus FZD10 VGNC VGNC:62403
Mus musculus FZD10 MGD MGI:2136761
Macaca mulatta FZD10 VGNC VGNC:72833
Bos taurus FZD10 VGNC VGNC:29166
Others FZD10 NCBI