DUSP6 - dual specificity phosphatase 6 Gene

Also Known as HH19; MKP3; PYST1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1848

About DUSP6

Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:89,347,235-89,352,501 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues, 30 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 46.5), fat (RPKM 44.7) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most Other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

DUSP6 Products (2)

mRNA	Protein	Name
NM_001946.4	NP_001937.2	dual specificity protein phosphatase 6 isoform a
NM_022652.4	NP_073143.2	dual specificity protein phosphatase 6 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	8670865	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12840032	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18771677	GOA
involved in negative regulation of MAPK cascade	IDA IDA: Inferred from direct assay	8670865	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	8670865	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10846176	GOA
involved in response to nitrosative stress	IEP IEP: Inferred from expression pattern	10846176	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8670865	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP6 Protein Structure

Rhodanese

DSPc

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase 6	MAP kinase phosphatase 3

DUSP6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DUSP6	Q16828	PHB2	Homo sapiens	Q99623	Y2H Array	32814053
Intra	DUSP6	Q16828	PHB2	Homo sapiens	Q99623	Y2H Pooling	32814053
Intra	DUSP6	Q16828	PHB2	Homo sapiens	Q99623	Validated Y2H	32814053
Intra	DUSP6	Q16828	MAPK3	Homo sapiens	P27361	Anti Tag CoIP	31980649
Intra	DUSP6	Q16828	MAPK3	Homo sapiens	P27361	Anti Tag CoIP	27880917
Intra	DUSP6	Q16828	MAPK3	Homo sapiens	P27361	CoIP	12840032
Intra	DUSP6	Q16828	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	31980649
Intra	DUSP6	Q16828	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	27880917

Cross: Cross-species interaction Intra: Intraspecies interaction

DUSP6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82535	DUSP6 Antibody (YA2280)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P82535A	DUSP6 Antibody (YA2280)(PBS only)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypogonadotropic Hypogonadism 19 With Or Without Anosmia	HH19 Hypogonadism, Hypogonadotropic, Type 19 With/Without Anosmia
Normosmic Congenital Hypogonadotropic Hypogonadism	Normosmic Idiopathic Hypogonadotropic Hypogonadism Nihh
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia	Idiopathic Hypogonadotropic Hypogonadism HH7 Hypogonadism, Isolated Hypogonadotropic Ihh Hypogonadism, Isolated, Hypogonadotropic Hypogonadotropic Hypogonadism Isolated Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism 7 Without Anosmia Congenital Hypogonadotropic Hypogonadism Normosmic Hh Klinefelter Syndrome Isolated Gonadotropin Deficiency
Congenital Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Mucositis	Inflammatory Disease Of Mucous Membrane Gastrointestinal Mucositis
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Scoliosis
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115502	BCI	Inhibitor	99.73%	Unkown
HY-115502A	BCI hydrochloride	Inhibitor	99.93%	Unkown
HY-168012	Pan-RAS-IN-6	Inhibitor	/	Unkown
HY-RS04067	DUSP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-126390	(E/Z)-BCI		99.38%	Unkown
HY-181889	KRAS G12C-IN-75	Inhibitor	/	Unkown
HY-RS17007	Dusp6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23450	Dusp6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DUSP6	RGD	RGD:70978
Macaca mulatta	DUSP6	VGNC	VGNC:72013
Canis familiaris	DUSP6	VGNC	VGNC:40135
Bos taurus	DUSP6	VGNC	VGNC:28262
Mus musculus	DUSP6	MGD	MGI:1914853
Felis catus	DUSP6	VGNC	VGNC:61669
Others	DUSP6	NCBI