STT3A - STT3 oligosaccharyltransferase complex catalytic subunit A Gene

Also Known as TMC; ITM1; STT3-A; CDG1WAD; CDG1WAR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3703

About STT3A

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,591,769-125,623,091 (from NCBI)

This gene has 17 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 5 phenotypes. Ubiquitous expression in thyroid (RPKM 41.7), endometrium (RPKM 25.2) and 25 other tissues.

Summary

The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

STT3A Products (3)

mRNA	Protein	Name
NM_001278503.2	NP_001265432.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform a
NM_001278504.2	NP_001265433.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform b
NM_152713.5	NP_689926.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP IMP: Inferred from mutant phenotype	19167329	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in co-translational protein modification	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in protein N-linked glycosylation	IMP IMP: Inferred from mutant phenotype	22467853	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	19167329	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	22467853	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STT3A Protein Structure

STT3

0
200
400
600
705 a.a.

Protein Preferred Names	Protein Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A	B5

STT3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STT3A	P46977	POMK	Homo sapiens	Q9H5K3	Anti Tag CoIP	32707033
Cross	STT3A	P46977	ns7b_sars2	SARS-CoV-2	P0DTD8	Anti Tag CoIP	36217030
Intra	STT3A	P46977	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	21903422
Intra	STT3A	P46977	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	STT3A	P46977	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	STT3A	P46977	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	STT3A	P46977	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	STT3A	P46977	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	STT3A	P46977	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	STT3A	P46977	RPN1	Homo sapiens	P04843	Anti Tag CoIP	35271311
Intra	STT3A	P46977	RPN1	Homo sapiens	P04843	Crosslink	30021884
Cross	STT3A	P46977	Sarm1	Mus musculus	Q6PDS3	Anti Tag CoIP	21903422
Intra	STT3A	P46977	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	STT3A	P46977	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	STT3A	P46977	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	STT3A	P46977	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	STT3A	P46977	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	STT3A	P46977	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Congenital Disorder Of Glycosylation, Type Iw, Autosomal Recessive	Stt3a-Cdg Cdg-Iw CDG1W Congenital Disorder Of Glycosylation Type Iw CDG1WAR Cdg Syndrome Type Iw Congenital Disorder Of Glycosylation Type 1w Congenital Disorder Of Glycosylation 1w Cdgiw Cdg Iw
Congenital Disorder Of Glycosylation, Type Iw, Autosomal Dominant	CDG1WAD Congenital Disorder Of Glycosylation 1w, Autosomal Dominant
Osteogenesis Imperfecta, Type X	Osteogenesis Imperfecta Type 10 OI10 Osteogenesis Imperfecta Type X Oi, Type X Osteogenesis Imperfecta 10 Oi Type X Oi-X
Granular Cell Carcinoma	Granular Cell Cancer Granular Cell Adenocarcinoma
Immunodeficiency 47	Congenital Disorder Of Glycosylation Type Ii CDG2E Congenital Disorder Of Glycosylation Type Iie IMD47 Cdg2s Cdg Iis Cdgiis Immunodeficiency And Hepatopathy With Or Without Neurologic Features Congenital Disorder Of Glycosylation, Type Ii CDG1I Congenital Disorder Of Glycosylation, Type Iie Cdg Iie Congenital Disorder Of Glycosylation Type 2e Congenital Disorder Of Glycosylation, Type Iis Cdg Ii Cdgii Cdgiie Carbohydrate Deficient Glycoprotein Syndrome Type Iie Cdg Syndrome Type Iie Congenital Disorder Of Glycosylation Ii Congenital Disorder Of Glycosylation 1i Cdg-Iie Alg2-Cdg Cdg-Ii Glycosylation, Congenital Disorder Of, Type Ii Cdgiide Congenital Disorder Of Glycosylation Type Iis Cog7-Cdg Cdg Syndrome Type Ii Carbohydrate Deficient Glycoprotein Syndrome Type Ii Congenital Disorder Of Glycosylation Type 1i Mannosyltransferase 2 Deficiency Congenital Disorder Of Glycosylation 2e Congenital Disorder Of Glycosylation 2s Congenital Disorders Of Glycosylation Type Ii Glycosylation, Congenital Disorder Of, Type Iie Immunodeficiency, Type 47 Congenital Disorder Of Glycosylation Type 2a
Deafness, Autosomal Dominant 36	DFNA36 Autosomal Dominant Nonsyndromic Deafness 36 Autosomal Dominant Deafness 36 Deafness, Autosomal Dominant, 36 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 36 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 36 Deafness, Autosomal Dominant, Type 36
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Capillary Malformations, Congenital	Familial Multiple Nevi Flammei Nevi Flammei, Familial Multiple CMC Port-Wine Stain Capillary Malformations Cmal Familial Multiple Port-Wine Stains Capillary Malformation Capillary Malformations, Congenital, 1, Somatic, Mosaic Congenital Capillary Malformations Port-Wine Stain Familial Multiple Hereditary Capillary Malformations Capillary Malformations, Hereditary Capillary Malformations, Congenital, Type 1, Somatic, Mosaic Strawberry Nevus Of Skin Naevus Flammeus
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Autosomal Dominant Nonsyndromic Deafness	Autosomal Dominant Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117383	NGI-1	Inhibitor	99.97%	Unkown
HY-175674	NGI-235	Inhibitor	99.70%	Unkown
HY-169003	STT3A/B-IN-1	Inhibitor	99.15%	Unkown
HY-169003A	(R,S)-STT3A/B-IN-1	Inhibitor	99.16%	Unkown
HY-176433	NSC-323241	Inhibitor	/	Unkown
HY-182914	NGI-189		99.29%	Unkown
HY-RS13970	STT3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STT3A	VGNC	VGNC:78263
Mus musculus	STT3A	MGD	MGI:105124
Felis catus	STT3A	VGNC	VGNC:67864
Canis familiaris	STT3A	VGNC	VGNC:46948
Rattus norvegicus	STT3A	RGD	RGD:1565793
Bos taurus	STT3A	VGNC	VGNC:35427
Others	STT3A	NCBI