DENND2B - DENN domain containing 2B Gene

Also Known as ST5; HTS1; p126

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6764

Summary

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
Ubiquitous expression in endometrium (RPKM 30.7), testis (RPKM 16.0) and 24 other tissues.

DENND2B Products (1)

mRNA Protein Name
NG_029450.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
20937701 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
9632734 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DENND2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DENND2B P78524 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
DENND2B P78524 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
DENND2B P78524 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03686 DENND1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03691 DENND5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown