hAChE-IN-2
hAChE-IN-2 is a potent hAChE inhibitor, with an IC50 of 0.71 μM. hAChE-IN-2 can also inhibits tau-oligomerization, with an EC50 of 2.21 μM. hAChE-IN-2 exhibits neuroprotective activity.
For research use only. We do not sell to patients.
- Formula: C22H23FN4O2
- Molecular Weight:394.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
hAChE 0.71 μM (IC50) |
In Vitro
hAChE-IN-2 (compound 21) (1-10 μM) shows neuroprotective activity in SH-SY5Y cells transfected with WT tau[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 394.44
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Formula C22H23FN4O2
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SMILES
COC1=CC=CC(C(N2CCN(CC2)C3=CN=CC=N3)C4=CC=C(C=C4)F)=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hAChE-IN-2 Related Classifications
HY-149237 Related Classifications
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