Insulin
Insulin is the central anabolic hormone of glucose, lipid and protein metabolism, produced by beta cells of the pancreatic islets as preproinsulin and processed through proinsulin to a two-chain disulfide-linked peptide of A and B chains. Glucose entry via GLUT2 triggers calcium-dependent exocytosis, and insulin receptor activation recruits IRS/PI3K/AKT signaling to promote GLUT4-mediated glucose uptake, glycogen synthesis and lipogenesis. Insulin deficiency or resistance underlies type 1 and type 2 diabetes, making insulin the first recombinant protein drug and today a portfolio of rapid, long-acting and premixed analogs. Its close structural relatives IGF-1 and IGF-II act mainly through homologous but distinct receptors.
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Insulin Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
