Notch-3
Notch-3 stands out within the Notch receptor family for its highly restricted expression in vascular smooth muscle cells and pericytes of small arteries, where it regulates vessel maturation and arterial specification. Signaling follows the canonical scheme: Delta-like and Jagged ligand binding induces ADAM and gamma-secretase cleavage, releasing the intracellular domain that activates RBPJ-dependent transcription of HES and HEY genes. Unlike Notch-1 and Notch-2, Notch-3 is dispensable for most embryonic development but essential for postnatal vascular remodeling. Numerous cysteine-altering missense mutations clustered in its extracellular EGF-like repeats cause CADASIL, a hereditary small-vessel disease characterized by stroke and early-onset dementia.
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Notch-3 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
