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Cat. No.: HY-133981

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Desmethylene tadalafil

Desmethylene tadalafil is a metabolite of Tadalafil (HY-90009A). The formation of Desmethylene tadalafil mediated predominantly by CYP3A4.

For research use only. We do not sell to patients.

CAS No.: 171489-03-5
Formula: C₂₁H₁₉N₃O₄
Molecular Weight:377.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Desmethylene tadalafil Chemical Structure

CAS No.: 171489-03-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Desmethylene tadalafil is a metabolite of Tadalafil (HY-90009A). The formation of Desmethylene tadalafil mediated predominantly by CYP3A4^[1].

Chemical Information

CAS No. 171489-03-5
Molecular Weight 377.39
Formula C₂₁H₁₉N₃O₄
SMILES

O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(O)C(O)=C3)N14)NC5=C2C=CC=C5)N(C)CC4=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu J, et al. Cytochrome P450-mediated metabolic interactions between donepezil and tadalafil in human liver microsomes. Toxicol In Vitro. 2024 Oct;100:105922. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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