Didocosahexaenoin
Didocosahexaenoin, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells.
For research use only. We do not sell to patients.
- CAS No.: 124538-05-2
- Formula: C47H68O5
- Molecular Weight:713.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Didocosahexaenoin (10-50 μM; 96 hours) induces cell apoptosis in PC3 cells[1].
Didocosahexaenoin (1 nM-100 μM; 96 hours) induces dose-dependent cytotoxicity on human prostate cells[1].
Didocosahexaenoin (30, 50 μM; 24 hours) causes a significant fold change increase in the loss of mitochondrial membrane potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 cells
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Concentration:10, 20, 30, 40, 50 μM
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Incubation Time:24, 48 hours
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Result:Caused elevated levels of early apoptotic cells.
Significantly increased the level of activated caspase 3/7 for 6 h at 30 and 50 μM.
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Cell Line:PC3, DU145, A2780 and A2780-CP70 carcinoma cells and MCF-7 and LNCaP cells
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Concentration:1 nM-100 μM
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Incubation Time:96 hours
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Result:Induced dose-dependent cytotoxicity with the strongest toxicity under 10.0 μM on DU145 and PC3 cells, A2780 and A2780-CP70 with IC50 of 3.20 and 3.82 μM, 4.6, 5.53 μM, respectively.
Chemical Information
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CAS No. 124538-05-2
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Molecular Weight 713.04
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Formula C47H68O5
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SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O.OCC(CO)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Didocosahexaenoin Related Classifications
HY-148944 Related Classifications
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