Didocosahexaenoin
Didocosahexaenoin, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells.
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- CAS. Nr.: 124538-05-2
- Formel: C47H68O5
- Molecular Weight:713.04
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
Didocosahexaenoin (10-50 μM; 96 hours) induces cell apoptosis in PC3 cells[1].
Didocosahexaenoin (1 nM-100 μM; 96 hours) induces dose-dependent cytotoxicity on human prostate cells[1].
Didocosahexaenoin (30, 50 μM; 24 hours) causes a significant fold change increase in the loss of mitochondrial membrane potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 cells
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Concentration:10, 20, 30, 40, 50 μM
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Incubation Time:24, 48 hours
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Result:Caused elevated levels of early apoptotic cells.
Significantly increased the level of activated caspase 3/7 for 6 h at 30 and 50 μM.
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Cell Line:PC3, DU145, A2780 and A2780-CP70 carcinoma cells and MCF-7 and LNCaP cells
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Concentration:1 nM-100 μM
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Incubation Time:96 hours
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Result:Induced dose-dependent cytotoxicity with the strongest toxicity under 10.0 μM on DU145 and PC3 cells, A2780 and A2780-CP70 with IC50 of 3.20 and 3.82 μM, 4.6, 5.53 μM, respectively.
- Mitochondrial membrane-potential fluorescent assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Cell Cytotoxicity Assay
- Mammalian live/dead viability and cytotoxicity staining
- Annexin V plus membrane-impermeant dye apoptosis staining
- ROS/oxidative-stress fluorescent staining
- Fluorescent plasma-membrane potential dye assay
- Mitochondrial membrane-potential and mitochondrial mass staining
- Apoptosis Solutions
- Cell Viability Determination by MTT Colorimetric Assay
Chemical Information
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CAS. Nr. 124538-05-2
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Molecular Weight 713.04
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Formel C47H68O5
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SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O.OCC(CO)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (264 KB)
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SDS (252 KB)
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- Deutsch - DE (252 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Didocosahexaenoin Related Classifications
HY-148944 Related Classifications
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