2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Apoptosis
  4. Didocosahexaenoin

Didocosahexaenoin, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells.

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Didocosahexaenoin Chemical Structure

Didocosahexaenoin Chemical Structure

CAS No. : 124538-05-2

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Based on 1 publication(s) in Google Scholar

Didocosahexaenoin Related Antibodies

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Description

Didocosahexaenoin, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells[1].

In Vitro

Didocosahexaenoin (10-50 μM; 96 hours) induces cell apoptosis in PC3 cells[1].
Didocosahexaenoin (1 nM-100 μM; 96 hours) induces dose-dependent cytotoxicity on human prostate cells[1].
Didocosahexaenoin (30, 50 μM; 24 hours) causes a significant fold change increase in the loss of mitochondrial membrane potential[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Didocosahexaenoin Related Antibodies

Apoptosis Analysis[1]

Cell Line: PC3 cells
Concentration: 10, 20, 30, 40, 50 μM
Incubation Time: 24, 48 hours
Result: Caused elevated levels of early apoptotic cells.
Significantly increased the level of activated caspase 3/7 for 6 h at 30 and 50 μM.

Cell Cytotoxicity Assay[1]

Cell Line: PC3, DU145, A2780 and A2780-CP70 carcinoma cells and MCF-7 and LNCaP cells
Concentration: 1 nM-100 μM
Incubation Time: 96 hours
Result: Induced dose-dependent cytotoxicity with the strongest toxicity under 10.0 μM on DU145 and PC3 cells, A2780 and A2780-CP70 with IC50 of 3.20 and 3.82 μM, 4.6, 5.53 μM, respectively.
Molecular Weight

420.58

Formula

C25H40O5
CAS No.
SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O.OCC(CO)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Didocosahexaenoin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Didocosahexaenoin124538-05-2Reactive Oxygen SpeciesApoptosisomega-3diglycerideDHADHA triglyceridesmitochondrial membrane potentialROScytotoxicityprostate carcinomaInhibitorinhibitorinhibit

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