CGP71683
CGP 71683 Free base serves as a powerful and highly selective non-peptide antagonist targeting the NPY Y(5) receptor, making it a valuable tool in obesity research.
For research use only. We do not sell to patients.
- CAS No.: 192321-23-6
- Formula: C26H29N5O2S
- Molecular Weight:475.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Neuropeptide Y Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-1 | IC50 |
1.3 nM
Compound: CGP-71683A (Trans)
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Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 transiently expressed in COS-1 cells using [125I]PYY
Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 transiently expressed in COS-1 cells using [125I]PYY
|
[PMID: 15863317] |
| COS-1 | IC50 |
97 nM
Compound: CGP-71683A (Trans)
|
Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912
Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912
|
[PMID: 15863317] |
| HEK293 | IC50 |
3500 nM
Compound: CGP-71683A (Trans)
|
Inhibitory activity against mutated constitutively activated human Melanin concentrating hormone receptor 1 (CA-MCH-R1) stably expressed in HEK293 cells using [125I](Phe13, Tyr19) MCH
Inhibitory activity against mutated constitutively activated human Melanin concentrating hormone receptor 1 (CA-MCH-R1) stably expressed in HEK293 cells using [125I](Phe13, Tyr19) MCH
|
[PMID: 15863317] |
Chemical Information
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CAS No. 192321-23-6
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Molecular Weight 475.61
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Formula C26H29N5O2S
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SMILES
NC1=NC(NC[C@@H](CC2)CC[C@H]2CNS(=O)(C3=CC=CC4=CC=CC=C34)=O)=NC5=CC=CC=C51
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)