CDH5 - cadherin 5 Gene

Also Known as 7B4; CD144

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1003

About CDH5

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:66,366,691-66,404,784 (from NCBI)

This gene has 9 transcripts (splice variants), 127 orthologues and 33 paralogues. Biased expression in placenta (RPKM 108.8), lung (RPKM 57.5) and 12 other tissues.

Summary

This gene encodes a classical Cadherin of the Cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular Cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical Cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate Cancer. [provided by RefSeq, Nov 2015]

CDH5 Products (1)

mRNA	Protein	Name
NM_001795.5	NP_001786.2	cadherin-5 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables BMP receptor binding	IPI IPI: Inferred from physical interaction	26598555	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	18287330	GOA
enables fibrinogen binding	IMP IMP: Inferred from mutant phenotype	19413351	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15985432	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	28926625	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	11950700	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12088286	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19996314	GOA
enables vascular endothelial growth factor receptor 2 binding	IPI IPI: Inferred from physical interaction	25893857	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adherens junction organization	IDA IDA: Inferred from direct assay	26598555	GOA
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	25753039	GOA
involved in blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	31934175	GOA
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	15572031	GOA
involved in cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	26598555	GOA
involved in cell-cell junction assembly	IMP IMP: Inferred from mutant phenotype	23288152	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	23159740	GOA
acts upstream of negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	31934175	GOA
involved in negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	28112401	GOA
involved in negative regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	23159740	GOA
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	26598555	GOA
involved in positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	22391569	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	15572031	GOA
involved in positive regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	23288152	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26598555	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	26598555	GOA
involved in protein localization to bicellular tight junction	IMP IMP: Inferred from mutant phenotype	25753039	GOA
involved in regulation of establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	20332120	GOA
involved in regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	23159740	GOA
involved in regulation of vascular permeability	IDA IDA: Inferred from direct assay	26598555	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	21168935	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	25978380	GOA
located in adherens junction	IMP IMP: Inferred from mutant phenotype	26923917	GOA
located in cell surface	IDA IDA: Inferred from direct assay	23288152	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	15572031	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	25978380	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDH5 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
784 a.a.

Protein Preferred Names	Protein Names
cadherin-5	7B4 antigen

CDH5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDH5	P33151	CTNNB1	Homo sapiens	P35222	Competition Binding	18287330
Intra	CDH5	P33151	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	18662404
Intra	CDH5	P33151	CTNNB1	Homo sapiens	P35222	Imaging	17057644
Intra	CDH5	P33151	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	33961781
Intra	CDH5	P33151	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	28514442
Intra	CDH5	P33151	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	20123964
Intra	CDH5	P33151	WARS1	Homo sapiens	P23381	Pull Down	20010843
Intra	CDH5	P33151	PARD6A	Homo sapiens	Q9NPB6	Anti Bait CoIP	17057644
Intra	CDH5	P33151	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	17057644
Intra	CDH5	P33151	PARD3	Homo sapiens	Q8TEW0	Anti Bait CoIP	17057644

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDH5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73560A	VE-Cadherin Protein, Human (HEK293, His-Fc)	NP_001786.2 (A26-Q593)	≥ 90%, as determined by reducing SDS-PAGE.

CDH5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81097	VE-Cadherin Antibody (YA3491)	WB, ICC/IF, FC	Human
HY-P84265	VE-Cadherin Antibody (YA3962)	WB, FC, ELISA	Human, Rat
HY-P84265A	VE-Cadherin Antibody (YA3962)(PBS only)	WB, FC, ELISA	Human, Rat
HY-P85776	VE-Cadherin Antibody (YA5468)	IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86361	VE Cadherin Antibody (YA6053)	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat

Related Diseases

Diseases	Alias
Periapical Granuloma	Apical Granuloma
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Perineurioma	Soft Tissue Perineurioma
Central Serous Chorioretinopathy	Central Serous Chorioretinopathy After Bone Marrow Transplantation Central Serous Choroidopathy Cscr Central Serous Retinopathy Central Serous Choroidoretinopathy
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Hantavirus Pulmonary Syndrome	Hps Four Corners Hantavirus Hards Hantavirus Hantavirus-Associated Respiratory Distress Syndrome Hanta Virus Hantavirus Cardiopulmonary Syndrome Hps - [Hantavirus Pulmonary Syndrome] Hcps - [Hantavirus Cardiopulmonary Syndrome]
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Intussusception	Intussusception Of Intestine Invagination Of Intestine Or Colon
Angiosarcoma	Hemangiosarcoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Cerebrocostomandibular Syndrome	Cerebro-Costo-Mandibular Syndrome CCMS Rib Gap Defects With Micrognathia Ccm Syndrome
Dyssegmental Dysplasia, Silverman-Handmaker Type	DDSH Silverman-Handmaker Type Dyssegmental Dysplasia Dyssegmental Dysplasia Silverman-Handmaker Type Dyssegmental Dwarfism Silverman-Handmaker Type Dyssegmental Dwarfism, Silverman-Handmaker Type Anisospondylic Camptomicromelic Dwarfism, Silverman-Handmaker Type Anisospondylic Camptomicromelic Dwarfism Silverman-Handmaker Type Dysplasia, Dyssegmental, Silverman-Handmaker Type
Hantavirus Hemorrhagic Fever With Renal Syndrome	Hemorrhagic Fever, Russian Hemorrhagic Nephrosonephritis Hfrs Puumala Virus Nephropathy Hemorrhagic Fever With Renal Syndrome
Limb Ischemia
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Leukostasis
Diabetic Macular Edema
Nephrotic Syndrome, Type 10	NPHS10 Nephrotic Syndrome Type 10 Idiopathic Steroid-Sensitive Nephrotic Syndrome Nephrotic Syndrome 10
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Retinal Vascular Disease	Retinal Vascular Retinal Vascular Disorder Retina Circulation Disorder
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02338	CDH5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174735	Human CDH5 mRNA		/	Unkown
HY-RS18127	Cdh5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24601	Cdh5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDH5	VGNC	VGNC:70973
Felis catus	CDH5	VGNC	VGNC:60684
Bos taurus	CDH5	VGNC	VGNC:97252
Canis familiaris	CDH5	VGNC	VGNC:39033
Rattus norvegicus	CDH5	RGD	RGD:1307370
Mus musculus	CDH5	MGD	MGI:105057
Others	CDH5	NCBI