Bub1b - BUB1B, mitotic checkpoint serine/threonine kinase Gene

Also Known as BUBR1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12236

Summary

Predicted to enable protein kinase activity. Acts upstream of or within metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Located in kinetochore. Part of outer kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study mosaic variegated aneuploidy syndrome 1. Human ortholog(s) of this gene implicated in colorectal Cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Apr 2022]

Bub1b Products (1)

mRNA Protein Name
NM_009773.3 NP_033903.2 mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12925705 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
15767571 MGI
acts upstream of or within protein localization to chromosome, centromeric region IMP
IMP: Inferred from mutant phenotype
19283064 MGI
Cellular Component GO Annotation Evidence References Source
located in kinetochore IDA
IDA: Inferred from direct assay
12925705 MGI
located in kinetochore IMP
IMP: Inferred from mutant phenotype
17227893 MGI
part of outer kinetochore IDA
IDA: Inferred from direct assay
14519686 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitotic checkpoint serine/threonine-protein kinase BUB1 beta

  • MAD3/BUB1-related protein kinase

  • budding uninhibited by benzimidazoles 1 beta

  • budding uninhibited by benzimidazoles 1 homolog, beta

  • mitotic checkpoint kinase MAD3L

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-172089 TG101209 analog 1 Inducer 98.27% Unkown
HY-161865 Antitumor agent-180 Inducer 99.46% Unkown
HY-RS01682 BUB1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19413 Bub1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25905 Bub1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bub1b NCBI NCBI:701