DDAH2 - dimethylarginine dimethylaminohydrolase 2 Gene

Also Known as G6a; DDAH; NG30; DDAHII; HEL-S-277

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23564

About DDAH2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,727,040-31,730,263 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 188 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 29.0), fat (RPKM 28.2) and 24 other tissues.

Summary

This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]

DDAH2 Products (3)

mRNA	Protein	Name
NM_001303007.2	NP_001289936.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
NM_001303008.2	NP_001289937.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
NM_013974.3	NP_039268.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
NOT enables dimethylargininase activity	IDA IDA: Inferred from direct assay	21493890	GOA
NOT enables dimethylargininase activity	IGI IGI: Inferred from genetic interaction	37296100	GOA
NOT enables dimethylargininase activity	IMP IMP: Inferred from mutant phenotype	37296100	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in citrulline metabolic process	IDA IDA: Inferred from direct assay	21493890	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDAH2 Protein Structure

Amidinotransf

0
100
200
285 a.a.

Protein Preferred Names	Protein Names
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	S-phase protein

DDAH2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDAH2	O95865	IGFN1	Homo sapiens	Q86VF2-5	Validated Y2H	32296183
Intra	DDAH2	O95865	NOXA1	Homo sapiens	Q86UR1-2	Validated Y2H	32296183
Intra	DDAH2	O95865	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
Cross	DDAH2	O95865	P0C6X7-PRO_0000037314	Human SARS coronavirus	P0C6X7-PRO_0000037314	Y2H Pooling	22046132
Cross	DDAH2	O95865	P0C6X7-PRO_0000037314	Human SARS coronavirus	P0C6X7-PRO_0000037314	Lumier	22046132
Intra	DDAH2	O95865	ACTN3	Homo sapiens	Q08043	Validated Y2H	32296183
Intra	DDAH2	O95865	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	DDAH2	O95865	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	DDAH2	O95865	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

DDAH2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81702	DDAH2 Antibody (YA1447)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Arteriosclerosis	Arteriosclerotic Vascular Disease
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Esophageal Lipoma	Lipoma Of Esophagus
Diabetes Mellitus	Diabetes
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03605	DDAH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DDAH2	MGD	MGI:1859016
Macaca mulatta	DDAH2	VGNC	VGNC:81057
Canis familiaris	DDAH2	VGNC	VGNC:39828
Bos taurus	DDAH2	VGNC	VGNC:27940
Felis catus	DDAH2	VGNC	VGNC:61385
Rattus norvegicus	DDAH2	RGD	RGD:1302955
Others	DDAH2	NCBI