IGFBP6 - insulin like growth factor binding protein 6 Gene

Also Known as IBP6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3489

About IGFBP6

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,097,667-53,102,340 (from NCBI)

This gene has 5 transcripts (splice variants), 242 orthologues and 5 paralogues. Broad expression in fat (RPKM 60.7), prostate (RPKM 49.9) and 17 other tissues.

Summary

Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy. [provided by Alliance of Genome Resources, Apr 2022]

IGFBP6 Products (1)

mRNA	Protein	Name
NM_002178.3	NP_002169.1	insulin-like growth factor-binding protein 6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables insulin-like growth factor II binding	IMP IMP: Inferred from mutant phenotype	15308688	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24003225	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IDA IDA: Inferred from direct assay	24003225	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	24003225	GOA
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	24003225	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of insulin-like growth factor binary complex	IMP IMP: Inferred from mutant phenotype	15308688	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGFBP6 Protein Structure

IGFBP

Thyroglobulin_1

0
100
200
240 a.a.

Protein Preferred Names	Protein Names
insulin-like growth factor-binding protein 6	IBP-6

IGFBP6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGFBP6	P24592	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	IGFBP6	P24592	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	IGFBP6	P24592	CCDC28A	Homo sapiens	Q7Z6N9	Validated Y2H	32296183
Intra	IGFBP6	P24592	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	IGFBP6	P24592	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	IGFBP6	P24592	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	IGFBP6	P24592	C1orf74	Homo sapiens	Q96LT6	Validated Y2H	32296183
Intra	IGFBP6	P24592	PLEKHA7	Homo sapiens	Q6IQ23-2	Validated Y2H	32296183
Intra	IGFBP6	P24592	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	IGFBP6	P24592	POU4F2	Homo sapiens	Q12837	Validated Y2H	32296183
Intra	IGFBP6	P24592	RANBP10	Homo sapiens	Q6VN20	Validated Y2H	32296183
Intra	IGFBP6	P24592	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	IGFBP6	P24592	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	IGFBP6	P24592	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	IGFBP6	P24592	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	IGFBP6	P24592	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	32296183
Intra	IGFBP6	P24592	RABGGTB	Homo sapiens	P53611	Validated Y2H	32296183
Intra	IGFBP6	P24592	RABGGTB	Homo sapiens	P53611	Y2H Array	32296183
Intra	IGFBP6	P24592	RABGGTB	Homo sapiens	P53611	Y2H Prey Pooling	32296183
Intra	IGFBP6	P24592	EFEMP1	Homo sapiens	Q12805	Validated Y2H	32296183
Intra	IGFBP6	P24592	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	IGFBP6	P24592	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	IGFBP6	P24592	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	IGFBP6	P24592	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	IGFBP6	P24592	CCDC116	Homo sapiens	Q8IYX3	Validated Y2H	32296183
Intra	IGFBP6	P24592	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	IGFBP6	P24592	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	32296183
Intra	IGFBP6	P24592	NCALD	Homo sapiens	P61601	Validated Y2H	32296183
Intra	IGFBP6	P24592	SMCP	Homo sapiens	P49901	Y2H Array	32296183
Intra	IGFBP6	P24592	SMCP	Homo sapiens	P49901	Validated Y2H	32296183
Intra	IGFBP6	P24592	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183
Intra	IGFBP6	P24592	EPDR1	Homo sapiens	Q9UM22	Validated Y2H	32296183
Intra	IGFBP6	P24592	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	IGFBP6	P24592	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	IGFBP6	P24592	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGFBP6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73141	IGFBP-6 Protein, Human (HEK293, His)	P24592 (R28-G240)	≥ 95%, as determined by reducing SDS-PAGE.

IGFBP6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83331	IGFBP6 Antibody (YA3076)	WB	Human
HY-P83331A	IGFBP6 Antibody (YA3076)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
In Situ Carcinoma	Carcinoma In Situ
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Growth Retardation With Sensorineural Deafness And Mental Retardation Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Restriction With Sensorineural Deafness And Intellectual Disability Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Acth-Secreting Pituitary Adenoma	Acth-Producing Pituitary Adenoma Corticotroph Adenoma Corticotropinoma Pituitary-Dependent Cushing'S Disease Adrenal Gland Hyperfunction Cushing Syndrome
Vitreoretinopathy
Rhabdomyosarcoma
Sotos Syndrome	Cerebral Gigantism SOTOS Chromosome 5q35 Deletion Syndrome Sotos Syndrome 1, Formerly Sotos1, Formerly Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development Sotos Sequence Sotos' Syndrome Sotos1 Sotos Syndrome 1
Renal Osteodystrophy	Renal Rickets Chronic Kidney Disease-Mineral And Bone Disorder
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Middle Cerebral Artery Infarction	Infarction, Middle Cerebral Artery Infarction Middle Cerebral Artery
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06629	IGFBP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174647	Human IGFBP6 mRNA		/	Unkown
HY-RS18710	Igfbp6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25197	Igfbp6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IGFBP6	VGNC	VGNC:108351
Canis familiaris	IGFBP6	VGNC	VGNC:41907
Mus musculus	IGFBP6	MGD	MGI:96441
Bos taurus	IGFBP6	VGNC	VGNC:30088
Felis catus	IGFBP6	VGNC	VGNC:67716
Rattus norvegicus	IGFBP6	RGD	RGD:2877
Others	IGFBP6	NCBI