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PLAGL2 - PLAG1 like zinc finger 2 Gene

Also Known as ZNF900

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5326

About PLAGL2

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,192,504-32,207,743 (from NCBI)

This gene has 1 transcript (splice variant), 285 orthologues and 29 paralogues. Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues.

Summary

Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]

PLAGL2 Products (1)

mRNA	Protein	Name
NM_002657.3	NP_002648.1	zinc finger protein PLAGL2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15361364	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15361364	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAGL2 Protein Structure

zf-H2C2_2

zf-C2H2_4

zf-H2C2_2

zf-C2H2_4

0
100
200
300
400
496 a.a.

Protein Preferred Names	Protein Names
zinc finger protein PLAGL2	C2H2-type zinc finger protein

PLAGL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLAGL2	Q9UPG8	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pleomorphic Adenoma	Mixed Tumor Of The Salivary Gland Adenoma Pleomorphic Adenoma, Pleomorphic Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Cataract 30	Cataract 30 Pulverulent Cataract Coppock-Like Ctrct30 Dusty Cataract Cataract, Type 30
Gastrointestinal System Benign Neoplasm
Developmental And Epileptic Encephalopathy 1	Epileptic Encephalopathy, Early Infantile, 1 Infantile Epileptic-Dyskinetic Encephalopathy DEE1 Eiee1 Issx1 Xmesid X-Linked Infantile Spasm Syndrome 1 X-Linked Infantile Spasm Syndrome X-Linked Spasticity-Intellectual Disability-Epilepsy Syndrome Developmental And Epileptic Encephalopathy, 1 Infantile Epileptic Dyskinetic Encephalopathy Infantile Spasm Syndrome, X-Linked 1 West Syndrome, X-Linked Ohtahara Syndrome, X-Linked Early Infantile Epileptic Encephalopathy 1 Early Infantile Epileptic Encephalopathy-1 Issx X-Linked Ohtahara Syndrome X-Linked West Syndrome Infantile Spasm Syndrome X-Linked 1 Myoclonic Epilepsy X-Linked With Intellectual Disability And Spasticity Ohtahara Syndrome X-Linked West Syndrome X-Linked Encephalopathy, Epileptic, Early Infantile, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180281	PLAGL2-IN-1		/	Unkown
HY-RS10645	PLAGL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PLAGL2	VGNC	VGNC:68889
Macaca mulatta	PLAGL2	VGNC	VGNC:76160
Canis familiaris	PLAGL2	VGNC	VGNC:44640
Bos taurus	PLAGL2	VGNC	VGNC:32973
Rattus norvegicus	PLAGL2	RGD	RGD:1307999
Mus musculus	PLAGL2	MGD	MGI:1933165
Others	PLAGL2	NCBI