RASAL2 - RAS protein activator like 2 Gene

Also Known as NGAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9462

About RASAL2

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:178,094,104-178,478,850 (from NCBI)

This gene has 8 transcripts (splice variants), 230 orthologues and 10 paralogues. Ubiquitous expression in esophagus (RPKM 4.0), fat (RPKM 3.6) and 24 other tissues.

Summary

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RASAL2 Products (2)

mRNA Protein Name
NM_004841.5 NP_004832.1 ras GTPase-activating protein nGAP isoform 1
NM_170692.4 NP_733793.2 ras GTPase-activating protein nGAP isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14743216 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASAL2 Protein Structure

C2

C2: C2 domain (171 - 239)

RasGAP

RasGAP: GTPase-activator protein for Ras-like GTPase (348 - 519)

DUF3498

DUF3498: Domain of unknown function (DUF3498) (609 - 1110)

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  • 1139 a.a.
Protein Preferred Names Protein Names

ras GTPase-activating protein nGAP

  • RASAL2/ACVR1 fusion

RASAL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RASAL2 Q9UJF2 MIA2 Homo sapiens Q96PC5
Validated Y2H
25416956
Intra
RASAL2 Q9UJF2 NFKBIB Homo sapiens Q15653
TAP
14743216
Intra
RASAL2 Q9UJF2 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
RASAL2 Q9UJF2 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Cross
RASAL2 Q9UJF2 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11683 RASAL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RASAL2 VGNC VGNC:45362
Rattus norvegicus RASAL2 RGD RGD:1307566
Bos taurus RASAL2 VGNC VGNC:33738
Macaca mulatta RASAL2 VGNC VGNC:76670
Mus musculus RASAL2 MGD MGI:2443881
Felis catus RASAL2 VGNC VGNC:69248
Others RASAL2 NCBI