ZBTB5 - zinc finger and BTB domain containing 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9925

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in thyroid (RPKM 6.3), esophagus (RPKM 6.3) and 25 other tissues.

ZBTB5 Products (1)

mRNA Protein Name
NM_014872.3 NP_055687.1 zinc finger and BTB domain-containing protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19491398 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19491398 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19491398 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19491398 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB5 O15062 ZBTB7B Homo sapiens O15156-2
Y2H Prey Pooling
32296183
Intra
ZBTB5 O15062 ZBTB7B Homo sapiens O15156-2
Y2H Array
32296183
Intra
ZBTB5 O15062 ZBTB7B Homo sapiens O15156-2
Validated Y2H
32296183
Intra
ZBTB5 O15062 METTL5 Homo sapiens Q9NRN9
Validated Y2H
32296183
Intra
ZBTB5 O15062 DCX Homo sapiens O43602-2
Validated Y2H
32296183
Intra
ZBTB5 O15062 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
ZBTB5 O15062 BAG4 Homo sapiens O95429
Validated Y2H
32296183
Intra
ZBTB5 O15062 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
ZBTB5 O15062 SWAP70 Homo sapiens Q9UH65
Y2H Array
25416956
Intra
ZBTB5 O15062 DCX Homo sapiens O43602
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15968 ZBTB20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15972 ZBTB33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15959 ZBTB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15960 ZBTB10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15961 ZBTB11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15962 ZBTB12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15963 ZBTB14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15964 ZBTB16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15965 ZBTB17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15966 ZBTB18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15967 ZBTB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15969 ZBTB24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15970 ZBTB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15971 ZBTB32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15973 ZBTB38 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15974 ZBTB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15975 ZBTB40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15976 ZBTB43 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15977 ZBTB46 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15978 ZBTB48 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15979 ZBTB7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15980 ZBTB7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15981 ZBTB7C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15982 ZBTB9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18204 Zbtb16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19274 Zbtb7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19496 Zbtb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19758 Zbtb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20521 Zbtb9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21220 Zbtb17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21977 Zbtb12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24681 Zbtb16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25763 Zbtb7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25990 Zbtb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26255 Zbtb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27030 Zbtb9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27736 Zbtb17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28494 Zbtb12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown