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Cat. No.: HY-150965

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NDT-30805

NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC₅₀ of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₂N₆S
Molecular Weight:414.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NDT-30805 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

NLRP3

NLRP3 inflammasome

All NOD-like Receptor (NLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	>40 μM Compound: 50;NDT-30805	Inhibition of LPS-stimulated IL-6 release in human PBMC measured after 4 hrs by ELISA Inhibition of LPS-stimulated IL-6 release in human PBMC measured after 4 hrs by ELISA	[PMID: 35978696]
PBMC	IC₅₀	>40 μM Compound: 50;NDT-30805	Inhibition of LPS-stimulated TNF-alpha release in human PBMC measured after 4 hrs by ELISA Inhibition of LPS-stimulated TNF-alpha release in human PBMC measured after 4 hrs by ELISA	[PMID: 35978696]

In Vitro

NDT-30805 (0-2 μM; 30 min) inhibits IL-1β release in PBMCs^[1].
NDT-30805 (0-2 μM; 30 min) inhibits ASC speck formation in THP1-ASC-GFP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human PBMCs
Concentration:

0-2 μM
Incubation Time:

30 min
Result:

Inhibited IL-1β release in PBMCs with an IC₅₀ of 0.013 μM.

Cell Viability Assay^[1]

Cell Line:

THP1-ASC-GFP cells
Concentration:

0-2 μM
Incubation Time:

30 min
Result:

Inhibited ASC which is a component of NLRP3 inflammasome in PBMCs with an IC₅₀ of 0.034 μM.

Chemical Information

Molecular Weight 414.53
Formula C₂₃H₂₂N₆S
SMILES

S=C1C=C(CC2=NC=CC=C2)NC3=NC(NC4=C5CCCC5=CC6=C4CCC6)=NN13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. David H, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Medicinal Chemistry Letters. 2022. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NDT-30805

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NDT-30805 Related Classifications

HY-150965 Related Classifications