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Cat. No.: HY-121458

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Nemorosone

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Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells.

For research use only. We do not sell to patients.

Purity: 99.0%
CAS No.: 351416-47-2
Formula: C₃₃H₄₂O₄
Molecular Weight:502.68

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Nemorosone Chemical Structure

CAS No.: 351416-47-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells^[1]^[2].

IC₅₀ & Target

apoptosis^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	6.23 μg/mL Compound: Nemorosone	Cytotoxicity against cisplatin-resistant human A2780 cells after 24 hrs Cytotoxicity against cisplatin-resistant human A2780 cells after 24 hrs	[PMID: 18951805]
A2780	IC₅₀	6.75 μg/mL Compound: Nemorosone	Cytotoxicity against doxorubicin-resistant human A2780 cells after 24 hrs Cytotoxicity against doxorubicin-resistant human A2780 cells after 24 hrs	[PMID: 18951805]
A2780	IC₅₀	9.2 μg/mL Compound: Nemorosone	Cytotoxicity against human A2780 cells after 24 hrs Cytotoxicity against human A2780 cells after 24 hrs	[PMID: 18951805]
HCT-8	IC₅₀	4.07 μg/mL Compound: Nemorosone	Cytotoxicity against SN38-resistant human HCT8 cells after 24 hrs Cytotoxicity against SN38-resistant human HCT8 cells after 24 hrs	[PMID: 18951805]
HCT-8	IC₅₀	4.23 μg/mL Compound: Nemorosone	Cytotoxicity against human HCT8 cells after 24 hrs Cytotoxicity against human HCT8 cells after 24 hrs	[PMID: 18951805]
HCT-8	IC₅₀	4.44 μg/mL Compound: Nemorosone	Cytotoxicity against raltitrexed-resistant human HCT8 cells after 24 hrs Cytotoxicity against raltitrexed-resistant human HCT8 cells after 24 hrs	[PMID: 18951805]
HEK293	IC₅₀	4.2 μg/mL Compound: Nemorosone	Cytotoxicity against HEK293 cells after 24 hrs Cytotoxicity against HEK293 cells after 24 hrs	[PMID: 18951805]
HeLa	IC₅₀	2.9 μM Compound: 3, Natural NEM	Cytotoxicity against human HeLa cells after 72 hrs by resazurin assay Cytotoxicity against human HeLa cells after 72 hrs by resazurin assay	[PMID: 22944119]
HeLa	IC₅₀	3.3 μM Compound: nemorosone	Cytotoxicity against human HeLa cells after 24 to 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 to 48 hrs by MTT assay	[PMID: 19497755]
HT-29	IC₅₀	3.5 μg/mL Compound: Nemorosone	Cytotoxicity against SN38-resistant human HT-29 cells after 24 hrs Cytotoxicity against SN38-resistant human HT-29 cells after 24 hrs	[PMID: 18951805]
HT-29	IC₅₀	5.18 μg/mL Compound: Nemorosone	Cytotoxicity against 5-FU-resistant human HT-29 cells after 24 hrs Cytotoxicity against 5-FU-resistant human HT-29 cells after 24 hrs	[PMID: 18951805]
HT-29	IC₅₀	5.25 μg/mL Compound: Nemorosone	Cytotoxicity against human HT-29 cells after 24 hrs Cytotoxicity against human HT-29 cells after 24 hrs	[PMID: 18951805]
Jurkat	IC₅₀	4.6 μg/mL Compound: Nemorosone	Cytotoxicity against human Jurkat cells after 24 hrs Cytotoxicity against human Jurkat cells after 24 hrs	[PMID: 18951805]
K562	IC₅₀	4.2 μg/mL Compound: Nemorosone	Cytotoxicity against human K562 cells after 24 hrs Cytotoxicity against human K562 cells after 24 hrs	[PMID: 18951805]
LNCaP	IC₅₀	1.81 μg/mL Compound: Nemorosone	Cytotoxicity against etoposide-resistant human LNCAP cells after 24 hrs Cytotoxicity against etoposide-resistant human LNCAP cells after 24 hrs	[PMID: 18951805]
LNCaP	IC₅₀	2.12 μg/mL Compound: Nemorosone	Cytotoxicity against human LNCAP cells after 24 hrs Cytotoxicity against human LNCAP cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	3.3 μg/mL Compound: Nemorosone	Cytotoxicity against 5-FU-resistant human MCF7 cells after 24 hrs Cytotoxicity against 5-FU-resistant human MCF7 cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	4.28 μg/mL Compound: Nemorosone	Cytotoxicity against doxorubicin-resistant human MCF7 cells after 24 hrs Cytotoxicity against doxorubicin-resistant human MCF7 cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	4.37 μg/mL Compound: Nemorosone	Cytotoxicity against human MCF7 cells after 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs	[PMID: 18951805]
MCF7	IC₅₀	5.2 μM Compound: 3, Natural NEM	Cytotoxicity against human MCF7 cells after 72 hrs by resazurin assay Cytotoxicity against human MCF7 cells after 72 hrs by resazurin assay	[PMID: 22944119]
MIA PaCa-2	IC₅₀	2.4 μM Compound: 3, Natural NEM	Cytotoxicity against human MIAPaCa2 cells after 72 hrs by resazurin assay Cytotoxicity against human MIAPaCa2 cells after 72 hrs by resazurin assay	[PMID: 22944119]
NCI-H460	IC₅₀	4.21 μg/mL Compound: Nemorosone	Cytotoxicity against human H460 cells after 24 hrs Cytotoxicity against human H460 cells after 24 hrs	[PMID: 18951805]
NIH3T3	IC₅₀	>50 μg/mL Compound: Nemorosone	Cytotoxicity against Swiss mouse 3T3 cells after 24 hrs Cytotoxicity against Swiss mouse 3T3 cells after 24 hrs	[PMID: 18951805]
PC-3	IC₅₀	2.01 μg/mL Compound: Nemorosone	Cytotoxicity against human PC3 cells after 24 hrs Cytotoxicity against human PC3 cells after 24 hrs	[PMID: 18951805]

In Vitro

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC₅₀s of 25.7-27.1 μM, 22.8-64.3 μM, respectively^[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells^[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HT-29 and LoVo cells
Concentration:

0-50 μM
Incubation Time:

24-72 h
Result:

Inhibited the proliferation of HT-29 and LoVo cells with IC₅₀s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.

Cell Cycle Analysis^[1]

Cell Line:

HT-29 and LoVo cells
Concentration:

25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time:

24, 48 hours
Result:

Increased the percentage of G0/G1 phase cells.

Apoptosis Analysis^[1]

Cell Line:

HT-29 and LoVo cells
Concentration:

25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time:

24, 48 hours
Result:

Induced apoptosis in both cell lines.

In Vivo

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm³ MIA-PaCa-2 xenograft tumor^[2]
Dosage:

50 mg/kg
Administration:

Daily i.p. injections for 28 days
Result:

Showed a significant growth-inhibitory effect in pancreatic cancer xenografts^[2].

Chemical Information

CAS No. 351416-47-2
Appearance Solid
Molecular Weight 502.68
Formula C₃₃H₄₂O₄
Color White to off-white
SMILES

O=C(C1=CC=CC=C1)[C@@]23C([C@@](C(C(C/C=C(C)/C)=C2O)=O)(C[C@H](C/C=C(C)/C)C3(C)C)C/C=C(C)/C)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5):1827. Published 2020 Mar 6. [Content Brief]

[2]. Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8(9):e74555. Published 2013 Sep 5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Nemorosone

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

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References

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Help & FAQs

Nemorosone Related Classifications

HY-121458 Related Classifications