DMG-PEG2000-CREKA

DMG-PEG2000-CREKA is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. CREKA peptide: Targeting/functional ligand-the CREKA peptide is a tumor homing peptide that specifically binds to the fibroin-fibronectin complex deposited in tumor vessels, achieving tumor vascular targeting.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.