Dopamine D2 receptor modulator-1

Dopamine D2 receptor modulator-1 (Compound 6c) (0.01 nM; 10 min) acts as a potent positive allosteric modulator of hD2R expressed in CHO cells, increasing dopamine potency by 5.11-fold without intrinsic agonist activity^[1].
Dopamine D2 receptor modulator-1 (compound 6c) (0.1-100 μM; 30 min) shows no cytotoxicity and minimal interaction with P-glycoprotein in MDCK-MDR1 cells at concentrations up to 100 μM^[1].
Dopamine D2 receptor modulator-1 (compound 6c) (100 μM; 72 h) shows no significant cytotoxicity in HepG2 cells at 100 μM after 72 h of incubation^[1].
Dopamine D2 receptor modulator-1 (compound 6c) (100 μM; 48 h) exhibits no significant neurotoxicity in dopaminergic-differentiated SH-SY5Y cells at 100 μM after 48 h of incubation^[1].
Dopamine D2 receptor modulator-1 (compound 6c) (100 μM; 60 min preincubation, 48 h coincubation with 6-OHDA) provides significant neuroprotection against 6-OHDA-induced toxicity in dopaminergic-differentiated SH-SY5Y cells at 100 μM, with enhanced protection observed at 50-100 μM 6-OHDA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.