DOPE-PEG1000-WYRGRL

DOPE-PEG1000-WYRGRL is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against specific cell surface receptors in tumor and inflammatory microenvironments.
Composition and role of each component:
1. PEG1000 (polyethylene glycol, MW 1000): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
2. WYRGRL (WYRGRL peptide): Targeting ligand-a targeting peptide with the sequence tryptophan-tyrosine-arginine-glycine-arginine-leucine, designed to enhance tissue-specific binding. The WYRGRL motif has been explored for targeting specific cell populations in tumor and inflammatory microenvironments, utilizing its arginine-rich sequence to simultaneously achieve cell penetration and targeting functions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.