DOV-216,303
DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats.
For research use only. We do not sell to patients.
- CAS No.: 86215-36-3
- Formula: C11H12Cl3N
- Molecular Weight:264.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-18332C
DOV-216,303 Free BaseDAT/NET/SERT Inhibitor -
HY-14472
TesofensineDA/NE/5-HT Inhibitor -
HY-12850A
Dasotraline hydrochlorideSerotonin Transporter Inhibitor -
HY-B1272AS
Desipramine-d4Stable Isotope -
HY-18610A
DiclofensineNeuronal Monoamine Uptake Inhibitor -
HY-14472R
Tesofensine (Standard)DA/NE/5-HT Inhibitor -
HY-110019
Indatraline hydrochlorideMonoamine Transporter Inhibitor
Biological Activity
Description
IC50 & Target
14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT[2]
Chemical Information
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CAS No. 86215-36-3
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Molecular Weight 264.58
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Formula C11H12Cl3N
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SMILES
ClC1=C(C=C(C23CC2CNC3)C=C1)Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. [Content Brief]
[2]. Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. [Content Brief]
[3]. Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DOV-216,303 Related Classifications
HY-W061043 Related Classifications
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