DPPE-PEG2000-PTP

DPPE-PEG2000-PTP is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around the nanoparticle, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging the circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. PTP peptide: Targeting/functional ligand-the PTP peptide (KTLLPTP) can specifically bind to reticulin 1 (Plectin-1), which is mislocalized to the cell membrane surface during pancreatic cancer cell development, achieving targeted delivery to pancreatic cancer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.