2. Stem Cell/Wnt TGF-beta/Smad
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  4. DS01080522

DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer.

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DS01080522

DS01080522 화학구조

CAS No. : 2832159-84-7

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제품 설명

DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.8 nM (PRKACA kinase), 66 nM (CREB phosphorylation)[1]
In Vitro

DS01080522 (1-10 μM; 30 min) affects phosphorylation of CREB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DS01080522 Related Antibodies

Cell Viability Assay[1]

Cell Line: NIH/3T3 cells
Concentration: 1-10 μM
Incubation Time: 30 min
Result: Dose-dependently decreased the phosphorylation level of CREB which is a marker of intracellular PRAKACA inhibitory activity in NIH/3T3 cells with an IC50 value of 66 nM.
분자량

471.34

화학식

C23H20Cl2N4O3
CAS No.
SMILES

O=C(N[C@H]([C@@]1([H])C[C@H](O)CN1)C2=CC(Cl)=C(C#N)C=C2)C3=CC4=CC=NC(Cl)=C4C=C3OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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DS01080522 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS010805222832159-84-7DS 01080522DS-01080522PKAProtein kinase Aphosphorylationfibrolamellarhepatocellular carcinomaNIH/3T3cancerInhibitorinhibitorinhibit

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상품명:
DS01080522
Cat. No.:
HY-150073
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