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  4. DS69910557

DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.

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DS69910557

DS69910557 화학구조

CAS No. : 3032750-17-4

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

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DS69910557 Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis[1].

IC50 & Target

IC50: 0.08 μM (PTHR1)[1].
In Vitro

DS69910557 (compound 19e) has highly potent antagonistic activity for PTHR1 with an IC50 value of 0.08 μM[1].
DS69910557 (3 μM) exhibits excellent selectivity against human ether-a-go-go-related-gene (hERG) channel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DS69910557 Related Antibodies
In Vivo

DS69910557 (compound 19e) (p.o.; 5mg/kg) has potency to decrease the plasma calcium concentration in rats in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 5mg/kg
Administration: PO
Result: Showed excellent PK profile, high maximum plasma concentration and plasma exposure in rats.
분자량

611.53

화학식

C32H33Cl2FN4O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (163.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6352 mL 8.1762 mL 16.3524 mL
5 mM 0.3270 mL 1.6352 mL 3.2705 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 98.86%

SDS (251 KB)

COA (261 KB) HNMR (286 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6352 mL 8.1762 mL 16.3524 mL 40.8811 mL
5 mM 0.3270 mL 1.6352 mL 3.2705 mL 8.1762 mL
10 mM 0.1635 mL 0.8176 mL 1.6352 mL 4.0881 mL
15 mM 0.1090 mL 0.5451 mL 1.0902 mL 2.7254 mL
20 mM 0.0818 mL 0.4088 mL 0.8176 mL 2.0441 mL
25 mM 0.0654 mL 0.3270 mL 0.6541 mL 1.6352 mL
30 mM 0.0545 mL 0.2725 mL 0.5451 mL 1.3627 mL
40 mM 0.0409 mL 0.2044 mL 0.4088 mL 1.0220 mL
50 mM 0.0327 mL 0.1635 mL 0.3270 mL 0.8176 mL
60 mM 0.0273 mL 0.1363 mL 0.2725 mL 0.6814 mL
80 mM 0.0204 mL 0.1022 mL 0.2044 mL 0.5110 mL
100 mM 0.0164 mL 0.0818 mL 0.1635 mL 0.4088 mL
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DS69910557 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS699105573032750-17-4DS 69910557DS-69910557PTHRParathyroid hormone receptororalhuman parathyroid hormone receptor 1 (hPTHR1)hyperparathyroidismhypercalcemiamalignancyosteoporosisInhibitorinhibitorinhibit

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상품명:
DS69910557
Cat. No.:
HY-148350
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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