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Cat. No.: HY-184721A

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DSPE-PEG3400-COOH

DSPE-PEG3400-COOH is a conjugate composed of DSPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSPE-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, for targeted modification of liposomes/nanoparticles.

For research use only. We do not sell to patients.

CAS No.: 1403812-41-8
Formula: (C₂H₄O)nC₄₅H₈₆NO₁₂P
Molecular Weight:3400 (Average)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DSPE-PEG3400-COOH Chemical Structure

CAS No.: 1403812-41-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

The structure of DSPE-PEG-COOH comprises three key parts, each working synergistically:
DSPE: Acts as a hydrophobic anchor, responsible for securely embedding the entire molecule into the membrane structure of the lipid nanoparticles.
PEG chain: Acts as a hydrophilic spacer arm, forming a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.
COOH (carboxyl group): Located at the end of the PEG chain, it serves as a reaction interface, enabling covalent bonding with molecules containing amino or hydroxyl groups (such as antibodies, peptides, and fluorescent dyes) through efficient chemical reactions such as amidation and esterification, achieving targeting or tracking functions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1403812-41-8
Molecular Weight 3400 (Average)
Formula (C₂H₄O)nC₄₅H₈₆NO₁₂P
SMILES

OC(COCCOCC(NCCOP(OC[C@@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.