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Cat. No.: HY-161603

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EGFR/HER2-IN-14

EGFR/HER2-IN-14 (Compd 46) is an inhibitor of mutant EGFR/HER2s which are resistant to other drugs. EGFR/HER2-IN-14 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 3034701-54-4
Formula: C₃₂H₂₉N₇O₄
Molecular Weight:575.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

EGFR/HER2-IN-14 Chemical Structure

CAS No.: 3034701-54-4

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EGFR/HER2-IN-14 (Compd 46) is an inhibitor of mutant EGFR/HER2s which are resistant to other drugs. EGFR/HER2-IN-14 can be used for cancer research^[1].

All EGFR Isoforms :

In Vitro

EGFR/HER2-IN-14 shows IC₅₀s bellow 100 nM against EGFR exon 20 insASV/insSVD, HER2 exon 20 insGSP/insYVMA mutants EGFR/HER2s transformed Ba/F3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034701-54-4
Molecular Weight 575.62
Formula C₃₂H₂₉N₇O₄
SMILES

COC1=C(NC2=NC=C3C(N(C4=CC=CC(NC(C=C)=O)=C4)C(C(C5=CC=CC=C5)=C3)=O)=N2)C=CC(N6CCOCC6)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. John H, et al. Inhibitors of egfr or her2 and methods of use. WO2024073745A1. 2024-04-04

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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EGFR/HER2-IN-14

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR/HER2-IN-14 Related Classifications

HY-161603 Related Classifications